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LSU network hubs integrate abiotic and biotic stress responses via interaction with the superoxide dismutase FSD2.
J. Exp. Bot. 68, 1185-1197 (2017)
In natural environments, plants often experience different stresses simultaneously, and adverse abiotic conditions can weaken the plant immune system. Interactome mapping revealed that the LOW SULPHUR UPREGULATED (LSU) proteins are hubs in an Arabidopsis protein interaction network that are targeted by virulence effectors from evolutionarily diverse pathogens. Here we show that LSU proteins are up-regulated in several abiotic and biotic stress conditions, such as nutrient depletion or salt stress, by both transcriptional and post-translational mechanisms. Interference with LSU expression prevents chloroplastic reactive oxygen species (ROS) production and proper stomatal closure during sulphur stress. We demonstrate that LSU1 interacts with the chloroplastic superoxide dismutase FSD2 and stimulates its enzymatic activity in vivo and in vitro. Pseudomonas syringae virulence effectors interfere with this interaction and preclude re-localization of LSU1 to chloroplasts. We demonstrate that reduced LSU levels cause a moderately enhanced disease susceptibility in plants exposed to abiotic stresses such as nutrient deficiency, high salinity, or heavy metal toxicity, whereas LSU1 overexpression confers significant disease resistance in several of these conditions. Our data suggest that the network hub LSU1 plays an important role in co-ordinating plant immune responses across a spectrum of abiotic stress conditions.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Abiotic Stress ; Arabidopsis Thaliana ; Biotic Stress ; Combinatorial Stress ; Low Sulphur Upregulated ; Lsu1; Induced Stomatal Closure; Plant Immune-system; Abscisic-acid; Hydrogen-peroxide; Guard-cells; Arabidopsis-thaliana; Drought Stress; Pseudomonas-syringae; Disease Resistance; Oxidative Stress
ISSN (print) / ISBN
0022-0957
e-ISSN
1460-2431
Journal
Journal of Experimental Botany
Quellenangaben
Volume: 68,
Issue: 5,
Pages: 1185-1197
Publisher
Oxford University Press
Publishing Place
Oxford
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Network Biology (INET)