PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Huckins, L.M.* ; Hatzikotoulas, K.* ; Southam, L.* ; Thornton, L.M.* ; Steinberg, J.* ; Aguilera-McKay, F.* ; Treasure, J.* ; Schmidt, U.* ; Gunasinghe, C.* ; Romero, A.M.* ; Curtis, C.* ; Rhodes, D.* ; Moens, J.* ; Kalsi, G.* ; Dempster, D.* ; Leung, R.* ; Keohane, A.* ; Burghardt, R.* ; Ehrlich, S.* ; Hebebrand, J.* ; Hinney, A.* ; Ludolph-Donislawski, A. ; Walton, E.* ; Deloukas, P.* ; Hofman, A.* ; Palotie, A.* ; Palta, P.* ; van Rooij, F.J.A.* ; Stirrups, K.* ; Adan, R.A.* ; Boni, C.* ; Cone, R.D.* ; Dedoussis, G.* ; van Furth, E.F.* ; Gonidakis, F.* ; Gorwood, P.* ; Hudson, J.I.* ; Kaprio, J.* ; Kas, M.J.* ; Keski-Rahonen, A.* ; Kiezebrink, K.* ; Knudsen, G.P.* ; Slof-Op 't Landt, M.C.T.* ; Maj, M.* ; Monteleone, A.M.* ; Monteleone, P.* ; Raevuori, A.H.* ; Reichborn-Kjennerud, T.* ; Tozzi, F.* ; Tsitsika, A.* ; van Elburg, A.A.* ; Collier, D.A.* ; Sullivan, P.F.* ; Breen, G.* ; Bulik, C.M.* ; Zeggini, E.*

Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa.

Mol. Psychiatry 23, 1169-1180 (2018)
Publ. Version/Full Text Research data DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Anorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with dangerously low body weight, and a deep and persistent fear of gaining weight. To date, only one genome-wide significant locus associated with AN has been identified. We performed an exome-chip based genome-wide association studies (GWAS) in 2158 cases from nine populations of European origin and 15 485 ancestrally matched controls. Unlike previous studies, this GWAS also probed association in low-frequency and rare variants. Sixteen independent variants were taken forward for in silico and de novo replication (11 common and 5 rare). No findings reached genome-wide significance. Two notable common variants were identified: rs10791286, an intronic variant in OPCML (P=9.89 × 10(-6)), and rs7700147, an intergenic variant (P=2.93 × 10(-5)). No low-frequency variant associations were identified at genome-wide significance, although the study was well-powered to detect low-frequency variants with large effect sizes, suggesting that there may be no AN loci in this genomic search space with large effect sizes.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
11.640
2.395
18
25
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2018
Prepublished in Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 1359-4184
e-ISSN 1476-5578
Journal Molecular Psychiatry
Quellenangaben Volume: 23, Issue: 5, Pages: 1169-1180 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Reviewing status Peer reviewed
Institute(s) Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology (EPI)
POF-Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504100-001
G-504000-007
DOI 10.1038/mp.2017.88
WOS ID WOS:000431614600009
PubMed ID 29155802
Erfassungsdatum 2017-11-27
[➜Report correction]