PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Balsevich, G.* ; Häusl, A.S.* ; Meyer, C.W. ; Karamihalev, S.* ; Feng, X.* ; Pöhlmann, M.L.* ; Dournes, C.* ; Uribe-Marino, A.* ; Santarelli, S.* ; Labermaier, C.* ; Hafner, K.* ; Mao, T.* ; Breitsamer, M.* ; Theodoropoulou, M.* ; Namendorf, C.* ; Uhr, M.* ; Paez-Pereda, M.* ; Winter, G.* ; Hausch, F.* ; Chen, A.* ; Tschöp, M.H. ; Rein, T.* ; Gassen, N.C.* ; Schmidt, M.V.*

Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function.

Nat. Commun. 8:1725 (2017)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The co-chaperone FKBP5 is a stress-responsive protein-regulating stress reactivity, and its genetic variants are associated with T2D related traits and other stress-related disorders. Here we show that FKBP51 plays a role in energy and glucose homeostasis. Fkbp5 knockout (51KO) mice are protected from high-fat diet-induced weight gain, show improved glucose tolerance and increased insulin signaling in skeletal muscle. Chronic treatment with a novel FKBP51 antagonist, SAFit2, recapitulates the effects of FKBP51 deletion on both body weight regulation and glucose tolerance. Using shorter SAFit2 treatment, we show that glucose tolerance improvement precedes the reduction in body weight. Mechanistically, we identify a novel association between FKBP51 and AS160, a substrate of AKT2 that is involved in glucose uptake. FKBP51 antagonism increases the phosphorylation of AS160, increases glucose transporter 4 expression at the plasma membrane, and ultimately enhances glucose uptake in skeletal myotubes. We propose FKBP51 as a mediator between stress and T2D development, and potential target for therapeutic approaches.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
12.124
2.995
44
45
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Diet-induced Obesity; Skeletal-muscle; Glucocorticoid-receptor; Glut4 Translocation; Immunophilin Fkbp51; Insulin-resistance; Diabetes-mellitus; Gene-expression; Adipose-tissue; Mice Lacking
Language english
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 8, Issue: 1, Pages: , Article Number: 1725 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502200-001
PubMed ID 29170369
DOI 10.1038/s41467-017-01783-y
WOS ID WOS:000416229300011
Erfassungsdatum 2017-11-28
[➜Report correction]