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Nunes, A. ; Pansare, V.J.* ; Bézière, N. ; Kolokithas-Ntoukas, A. ; Reber, J. ; Bruzek, M.* ; Anthony, J.* ; Prud´homme, R.K.* ; Ntziachristos, V.

Quenched hexacene optoacoustic nanoparticles.

J. Mater. Chem. B 6, 44-55 (2017)
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Open Access Green
Optoacoustic (photoacoustic) imaging enables high-resolution optical imaging at depths well beyond optical microscopy, revolutionizing optical interrogation of tissues. Operation in the near-infrared (NIR) is nevertheless necessary to capitalize on the technology potential and reach depths of several centimeters. Using Flash NanoPrecipitation for highly-scalable single-step encapsulation of hydrophobic hexacene at self-quenching concentrations, we propose quenched fluorescence-dye nanoparticles as a potent alternative to NIR metal nanoparticles for strong optoacoustic signal generation. Comprehensive hexacene-based nanoparticle characterization was based on a 5-step approach that examined the physicochemical features (Step 1), optoacoustic signal generation (Step 2), stability (Step 3), biocompatibility (Step 4) and spectral sensitivity (Step 5). Using this characterization framework we showcase the discovery of two nanoparticle formulations, QH2-50 nm and QH2-100 nm that attain superior stability characteristics and optimal optoacoustic properties compared to gold standards commonly employed for near-infrared optoacoustics. We discuss encapsulation and self-quenching (ESQ) of organic dyes as a promising strategy to generate optimal optoacoustic particles.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Substituted Pentacene Derivatives; Carbon Nanotube Toxicity; Confined Impinging Jets; In-vivo; Flash Nanoprecipitation; Gold Nanoparticles; Fluorescent Nanoparticles; Protected Nanoparticles; Thermal-stability; Organic Actives
Language english
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 2050-750X
e-ISSN 2050-7518
Journal Journal of Materials Chemistry B: Materials for Biology and Medicine
Quellenangaben Volume: 6, Issue: 1, Pages: 44-55 Article Number: , Supplement: ,
Publisher Royal Society of Chemistry (RSC)
Publishing Place Cambridge
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505500-001
DOI 10.1039/C7TB02633A
WOS ID WOS:000418379700004
Scopus ID 85038948757
Erfassungsdatum 2017-12-11
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