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Holze, C.* ; Michaudel, C.* ; Mackowiak, C.* ; Haas, D.A.* ; Benda, C.* ; Hubel, P.* ; Pennemann, F.L.* ; Schnepf, D.* ; Wettmarshausen, J. ; Braun, M.* ; Leung, D.W.* ; Amarasinghe, G.K.* ; Perocchi, F. ; Staeheli, P.* ; Ryffel, B.* ; Pichlmair, A.*

Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway.

Nat. Immunol. 19, 130–140 (2017)
Postprint Research data DOI PMC
Open Access Green
Reactive oxygen species (ROS) are generated by virus-infected cells; however, the physiological importance of ROS generated under these conditions is unclear. Here we found that the inflammation and cell death induced by exposure of mice or cells to sources of ROS were not altered in the absence of canonical ROS-sensing pathways or known cell-death pathways. ROS-induced cell-death signaling involved interactions among the cellular ROS sensor and antioxidant factor KEAP1, the phosphatase PGAM5 and the proapoptotic factor AIFM1. Pgam5(-/-) mice showed exacerbated lung inflammation and proinflammatory cytokines in an ozone-exposure model. Similarly, challenge with influenza A virus led to increased infiltration of the virus, lymphocytic bronchiolitis and reduced survival of Pgam5(-/-) mice. This pathway, which we have called 'oxeiptosis', was a ROS-sensitive, caspase independent, non-inflammatory cell-death pathway and was important for protection against inflammation induced by ROS or ROS-generating agents such as viral pathogens.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Oxidative Stress; Nadph Oxidase; Molecular-mechanisms; Hydrogen-peroxide; Virus; Keap1; Protein; Necroptosis; Activation; Nrf2
Language english
Publication Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 1529-2908
e-ISSN 1529-2916
Journal Nature Immunology
Quellenangaben Volume: 19, Issue: 2, Pages: 130–140 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
POF-Topic(s) 30201 - Metabolic Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s) Helmholtz Diabetes Center
Genetics and Epidemiology
PSP Element(s) G-502295-001
G-553000-001
DOI 10.1038/s41590-017-0013-y
WOS ID WOS:000423435200013
Scopus ID 85038397780
PubMed ID 29255269
Erfassungsdatum 2017-12-26
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