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The role of micro RNAs in breast cancer metastasis: Preclinical Validation and potential therapeutic targets.
Cancer Genomics Proteomics 15, 17-39 (2018)
Despite the approval of several molecular therapies in the last years, breast cancer-associated death ranks as the second highest in women. This is due to metastatic disease, which represents a challenge for treatment. A better understanding of the molecular mechanisms of metastasis is, therefore, of paramount importance. In this review we summarize the role of micro RNAs (miRs) involved in metastasis of breast cancer. We present an overview on metastasis-promoting, -suppressing and context-dependent miRs with both activities. We have categorized the corresponding miRs according to their target classes, interaction with stromal cells or exosomes. The pathways affected by individual miRs are outlined in regard to in vitro properties, activity in metastasis-related in vivo models and clinical significance. Current approaches that may be suitable for therapeutic inhibition or restauration of miR activity are outlined. Finally, we discuss the delivery bottlenecks which present as a major challenge in nucleic acid (miR)-based therapies.
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2.432
0.708
34
42
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Publication type
Article: Journal article
Document type
Review
Keywords
Colonization Of Distinct Organs ; Epithelial-mesenchymal Transition (emt) ; Exosomes ; Mesenchymal-epithelial Transition (met) ; Metastasis-related In Vivo Models ; Migration And Invasion ; Review ; Tumor Cell/stromal Cell Interactions
Language
Publication Year
2018
Prepublished in Year
2017
HGF-reported in Year
2017
ISSN (print) / ISBN
1109-6535
e-ISSN
1790-6245
Journal
Cancer Genomics & Proteomics
Quellenangaben
Volume: 15,
Issue: 1,
Pages: 17-39
Publisher
International Institute of Anticancer Research
Reviewing status
Peer reviewed
Institute(s)
Institute of Functional Epigenetics (IFE)
POF-Topic(s)
30203 - Molecular Targets and Therapies
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-502890-001
WOS ID
WOS:000418675900002
Scopus ID
85040185985
PubMed ID
29275360
Erfassungsdatum
2018-01-24