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Skeletal muscle as an endocrine organ: The role of myokines in exercise adaptations.
Cold Spring Harbor Perspect. Med. 7:a029793 (2017)
Exercise stimulates the release of proteins with autocrine, paracrine, or endocrine functions produced in skeletal muscle, termedmyokines. Based on the current state of knowledge, the major physiological function of myokines is to protect the functionality and to enhance the exercise capacity of skeletal muscle. Myokines control adaptive processes in skeletal muscle by acting as paracrine regulators of fuel oxidation, hypertrophy, angiogenesis, inflammatory processes, and regulation of the extracellular matrix. Endocrine functions attributed to myokines are involved in body weight regulation, low-grade inflammation, insulin sensitivity, suppression of tumor growth, and improvement of cognitive function. Muscle-derived regulatory RNAs and metabolites, as well as the design of modified myokines, are promising novel directions for treatment of chronic diseases.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Activated Protein-kinase; Growth-factor-i; Interleukin-6 Messenger-rna; Human Myocyte Proliferation; Induced Insulin-resistance; Fatty-acid Oxidation; Diet-induced Obesity; Extracellular-matrix; Endurance Exercise; Igf-i
e-ISSN
2157-1422
Quellenangaben
Volume: 7,
Issue: 11,
Article Number: a029793
Publisher
Cold Spring Harbor Laboratory Press
Publishing Place
Cold Spring Harbor
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Reviewing status
Peer reviewed