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Simões, I.C.M.* ; Fontes, A. ; Pinton, P.* ; Zischka, H. ; Wieckowski, M.R.*

Mitochondria in non-alcoholic fatty liver disease.

Int. J. Biochem. Cell Biol. 95, 93-99 (2018)
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NAFLD is a common disease in Western society and ranges from steatosis to steatohepatitis and to end-stage liver disease. The molecular mechanisms that cause the progression of steatosis to severe liver damage are not fully understood. One suggested mechanism involves the oxidation of biomolecules by mitochondrial ROS which initiates a vicious cycle of exacerbated mitochondrial dysfunction and increased hepatocellular oxidative damage. This may ultimately pave the way for hepatic inflammation and liver failure. This review updates our current understanding of mitochondria-derived oxidative stress in the progression of NAFLD.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Mitochondria ; Steatosis ; Ros ; Nafld ; Nash; Gamma-coactivator 1-alpha; Oxidative Stress; Steatohepatitis; Diet; Steatosis; Mice; Pathogenesis; Lipotoxicity; Dysfunction; Progression
Language english
Publication Year 2018
Prepublished in Year 2017
HGF-reported in Year 2017
ISSN (print) / ISBN 1357-2725
e-ISSN 1878-5875
Journal International Journal of Biochemistry & Cell Biology, The
Quellenangaben Volume: 95, Issue: , Pages: 93-99 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Oxford
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Toxicology and Pharmacology (TOX)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505200-003
DOI 10.1016/j.biocel.2017.12.019
WOS ID WOS:000424720700011
Scopus ID 85039741946
PubMed ID 29288054
Erfassungsdatum 2018-01-25
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