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Mitochondria in non-alcoholic fatty liver disease.
Int. J. Biochem. Cell Biol. 95, 93-99 (2018)
NAFLD is a common disease in Western society and ranges from steatosis to steatohepatitis and to end-stage liver disease. The molecular mechanisms that cause the progression of steatosis to severe liver damage are not fully understood. One suggested mechanism involves the oxidation of biomolecules by mitochondrial ROS which initiates a vicious cycle of exacerbated mitochondrial dysfunction and increased hepatocellular oxidative damage. This may ultimately pave the way for hepatic inflammation and liver failure. This review updates our current understanding of mitochondria-derived oxidative stress in the progression of NAFLD.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Mitochondria ; Steatosis ; Ros ; Nafld ; Nash; Gamma-coactivator 1-alpha; Oxidative Stress; Steatohepatitis; Diet; Steatosis; Mice; Pathogenesis; Lipotoxicity; Dysfunction; Progression
ISSN (print) / ISBN
1357-2725
e-ISSN
1878-5875
Quellenangaben
Volume: 95,
Pages: 93-99
Publisher
Elsevier
Publishing Place
Oxford
Non-patent literature
Publications
Reviewing status
Peer reviewed