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Fluorescent polyvinylphosphonate bioconjugates for selective cellular delivery.
Chem. Eur. J. 24, 2584-2587 (2018)
To date, many poly(ethylene glycol) (PEG) and poly(N-isopropylacrylamide) (PNIPAAm) biomolecule conjugates have been described, but they often show long response times, are not bio-inert, or lose function in biological fluids. Herein, we present a modular synthetic approach to generate polyvinylphosphonate biomolecule conjugates. These conjugates exhibit a sharp phase transition temperature even under physiological conditions where few other examples with this property have been described to date. Furthermore, it was feasible to add biological functions to the polymers via the conjugation step. The polyvinylphosphonate cholesterol constructs are attached to the cellular membrane and the folic acid anchored polymers are shuttled into the cells. This is an exceptional finding through a straightforward synthetic approach.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Delivery ; Fluorescent Polymer Bioconjugate ; Selective Cellular Targeting ; Thermoresponsive Polymer ; Thiol-ene Click Chemistry; Group-transfer Polymerization; Membrane Imaging Reagent; Serum-albumin; Cholesterol; Cancer; Cells; Nanoparticles; Polymersomes; Micelles; Tissues
ISSN (print) / ISBN
0947-6539
e-ISSN
1521-3765
Journal
Chemistry - A European Journal
Quellenangaben
Volume: 24,
Issue: 11,
Pages: 2584-2587
Publisher
Wiley
Publishing Place
Weinheim
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
CF Immunoanalytics (IMA)