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Open Access Green as soon as Postprint is submitted to ZB.
Lung cancer in pulmonary fibrosis: Tales of epithelial cell plasticity.
Respiration 81, 353-358 (2011)
Lung epithelial cells exhibit a high degree of plasticity. Alterations to lung epithelial cell function are critically involved in several chronic lung diseases such as pulmonary fibrosis. Pulmonary fibrosis is characterized by repetitive injury and subsequent impaired repair of epithelial cells, which leads to aberrant growth factor activation and fibroblast accumulation. Increased proliferation and hyper- and metaplasia of epithelial cells upon injury have also been observed in pulmonary fibrosis; this epithelial cell activation might represent the basis for lung cancer development. Indeed, several studies have provided histopathological evidence of an increased incidence of lung cancer in pulmonary fibrosis. The mechanisms involved in the development of cancer in pulmonary fibrosis, however, remain poorly understood. This review highlights recently uncovered molecular mechanisms shared between lung cancer and fibrosis, which extend the current evidence of a common trait of cancer and fibrosis, as provided by histopathological observations.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Pulmonary fibrosis; Lung cancer; Alveolar epithelium
ISSN (print) / ISBN
0025-7931
e-ISSN
1423-0356
Journal
Respiration
Quellenangaben
Volume: 81,
Issue: 5,
Pages: 353-358
Publisher
Karger
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Lung Health and Immunity (LHI)