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Analyses of HBV cccDNA quantification and modification.
Methods Mol. Biol. 1540, 59-72 (2017)
Covalently closed circular DNA (cccDNA) serves as the transcriptional template of hepatitis B virus (HBV) replication in the nucleus of infected cells. It ensures the persistence of HBV even if replication is blocked. Immune-mediated killing of infected hepatocytes, cell division, or cytokine induced non-cytolytic degradation of cccDNA can induce the loss of cccDNA. For studies on HBV control, the analysis of cccDNA integrity and its exact quantification is very important. Here, we describe different methods for HBV cccDNA quantification and modification.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Covalently Closed Circular Dna ; Deamination ; Differential Dna Denaturation Pcr ; Quantitative Pcr ; Quantitative Differential Dna Denaturation Pcr
Language
english
Publication Year
2017
HGF-reported in Year
2017
ISSN (print) / ISBN
1064-3745
e-ISSN
1940-6029
Book Volume Title
Hepatitis B Virus
Journal
Methods in Molecular Biology
Quellenangaben
Volume: 1540,
Pages: 59-72
Publisher
Springer
Publishing Place
Berlin [u.a.]
Reviewing status
Peer reviewed
Institute(s)
Institute of Virology (VIRO)
POF-Topic(s)
30203 - Molecular Targets and Therapies
Research field(s)
Immune Response and Infection
PSP Element(s)
G-502700-003
Scopus ID
85006459327
PubMed ID
27975308
Erfassungsdatum
2018-01-31