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"Transcriptomics": Molecular diagnosis of inborn errors of metabolism via RNA-sequencing.
J. Inherit. Metab. Dis. 41, 525-532 (2018)
Flatworms of the species Schmidtea mediterranea are immortal-adult animals contain a large pool of pluripotent stem cells that continuously differentiate into all adult cell types. Therefore, single-cell transcriptome profiling of adult animals should reveal mature and progenitor cells. By combining perturbation experiments, gene expression analysis, a computational method that predicts future cell states from transcriptional changes, and a lineage reconstruction method, we placed all major cell types onto a single lineage tree that connects all cells to a single stem cell compartment. We characterized gene expression changes during differentiation and discovered cell types important for regeneration. Our results demonstrate the importance of single-cell transcriptome analysis for mapping and reconstructing fundamental processes of developmental and regenerative biology at high resolution.
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Times Cited
Times Cited
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4.092
1.398
19
18
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Planarian Schmidtea-mediterranea; Stem-cells; Rna-seq; Gene-expression; Regeneration; Pluripotency; Trajectories; Organism; Tissues; System
Language
english
Publication Year
2018
HGF-reported in Year
2018
ISSN (print) / ISBN
0141-8955
e-ISSN
1573-2665
Quellenangaben
Volume: 41,
Issue: 3,
Pages: 525-532
Publisher
Springer
Publishing Place
1200 New York Ave, Nw, Washington, Dc 20005 Usa
Reviewing status
Peer reviewed
Institute(s)
Institute of Human Genetics (IHG)
POF-Topic(s)
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-500700-001
WOS ID
WOS:000432732200021
Scopus ID
85040952400
PubMed ID
29372369
Erfassungsdatum
2018-03-22