PuSH - Publication Server of Helmholtz Zentrum München: The role of visceral and subcutaneous adipose tissue measurements and their ratio by magnetic resonance imaging in subjects with prediabetes, diabetes and healthy controls from a general population without cardiovascular disease.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Storz, C.* ; Heber, S.D.* ; Rospleszcz, S. ; Machann, J. ; Sellner, S.* ; Nikolaou, K.* ; Lorbeer, R.* ; Gatidis, S.* ; Elser, S.* ; Peters, A. ; Schlett, C.L.* ; Bamberg, F.*

The role of visceral and subcutaneous adipose tissue measurements and their ratio by magnetic resonance imaging in subjects with prediabetes, diabetes and healthy controls from a general population without cardiovascular disease.

Br. J. Radiol. 91 (2018)

Publ. Version/Full Text

Postprint

DOI

PMC

	Open Access Green

Abstract
Metrics
Extra information

Objective: To study the relationship of area- and volumetric-based visceral and subcutaneous adipose tissue (VAT and SAT) by MRI and their ratio in subjects with impaired glucose metabolism from the general population.Methods: Subjects from a population-based cohort with established prediabetes, diabetes and healthy controls without prior cardiovascular diseases underwent 3 T MRI. VAT and SAT were assessed as total volume and area on a single slice, and their ratio (VAT/SAT) was calculated. Clinical covariates and cardiovascular risk factors, such as hypertension and glycemic state were assessed in standardized fashion, Univariate and adjusted analyses were conducted.Results: Among 384 subjects (age: 56.2 +/- 9.2 years, 581% male) with complete MRI data available, volumetric and single-slice VAT, SAT and VAT/SAT ratio were strongly correlated (all >r = 0.89), Similarly, VAT/SAT(volum)(e). ratio was strongly correlated with VAT(volume), but not with SAT (r = 0.72 and r = -0.21, respectively). Significant higher levels of VAT, SAT and VAT/SAT ratio were found in subjects with impaired glucose metabolism (all p <= 0.01). After adjustment for potential cardiovascular confounders, VAT(volume) and VAT/SAT(volume) ratio remained significantly higher in subjects with impaired glucose metabolism (VAT(volume) = 6.9 +/- 2.5 I and 3.4 +/- 2.3 I; VAT/SAT(volume) ratio = 0.82 +/- 0.34 I and 0.49 +/- 0,29 I in patients with diabetes and controls, respectively, all p < 0.02), whereas the association for SAT(volume) attenuated. Additionally, there was a decreasing effect of glycemic status on VAT/SAT(volume) ratio with increasing body mass index and waist circumference (p < 0.05).Conclusions: VAT(volume) and VAT/SAT volume ratio are associated with impaired glucose metabolism, independent of cardiovascular risk factors or MRI-based quantification technique, with a decreasing effect of VAT/SAT(volume) ratio in obese subjects.Advances in knowledge: Quantification of VAT(volume) and VAT/SAT(volume). ratio by MRI represents a reproducable biomarker associated with cardiometabolic risk factors in subjects with impaired glucose metabolism, while the association of VAT/SAT(volume) ratio with glycemic state is attenuated in obese subjects.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

1.814

0.918