PuSH - Publication Server of Helmholtz Zentrum München: Message in a microbottle: Modulation of vascular inflammation and atherosclerosis by extracellular vesicles.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

van der Vorst, E.P.C.* ; de Jong, R.J. ; Donners, M.M.P.C.*

Message in a microbottle: Modulation of vascular inflammation and atherosclerosis by extracellular vesicles.

Front. Cardiovasc. Med. 5:2 (2018)

Publ. Version/Full Text

DOI

PMC

	Open Access Gold

Abstract
Metrics
Extra information

Extracellular vesicles (EVs) have emerged as a novel intercellular communication system. By carrying bioactive lipids, miRNAs and proteins they can modulate target cell functions and phenotype. Circulating levels of EVs are increased in inflammatory conditions, e.g., cardiovascular disease patients, and their functional contribution to atherosclerotic disease development is currently heavily studied. This review will describe how EVs can modulate vascular cell functions relevant to vascular inflammation and atherosclerosis, particularly highlighting the role of EV-associated proteolytic activity and effector proteins involved. Furthermore, we will discuss key questions and challenges, especially for EV-based therapeutics.

Altmetric

Additional Metrics?

[➜Log in]