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Hartl, D.* ; Tirouvanziam, R.* ; Laval, J.* ; Greene, C.M.* ; Habiel, D.M.* ; Sharma, L.* ; Yildirim, A.Ö. ; Dela Cruz, C.S.* ; Hogaboam, C.M.*

Innate immunity of the lung: From basic mechanisms to translational medicine.

J. Innate Immun. 10, 487-501 (2018)
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Open Access Gold
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The respiratory tract is faced daily with 10,000 L of inhaled air. While the majority of air contains harmless environmental components, the pulmonary immune system also has to cope with harmful microbial or sterile threats and react rapidly to protect the host at this intimate barrier zone. The airways are endowed with a broad armamentarium of cellular and humoral host defense mechanisms, most of which belong to the innate arm of the immune system. The complex interplay between resident and infiltrating immune cells and secreted innate immune proteins shapes the outcome of host-pathogen, host-allergen, and host-particle interactions within the mucosal airway compartment. Here, we summarize and discuss recent findings on pulmonary innate immunity and highlight key pathways relevant for biomarker and therapeutic targeting strategies for acute and chronic diseases of the respiratory tract. (c) 2018 S. Karger AG, Basel
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Publication type Article: Journal article
Document type Review
Keywords Lung ; Immunity ; Immune Cells ; Neutrophils ; Macrophages ; Innate Lymphoid Cells ; Epithelial Cells; Invariant T-cells; Neutrophil Extracellular Traps; Obstructive Pulmonary-disease; Human Chitotriosidase Gene; Cystic-fibrosis Airways; Vitamin-b Metabolites; Sweet Taste Receptors; Lymphoid-cells; Mait Cells; Cxcr2 Antagonist
Language english
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 1662-811X
e-ISSN 1662-8128
Journal Journal of Innate Immunity
Quellenangaben Volume: 10, Issue: 5-6, Pages: 487-501 Article Number: , Supplement: ,
Publisher Karger
Publishing Place Allschwilerstrasse 10, Ch-4009 Basel, Switzerland
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-505000-007
DOI 10.1159/000487057
WOS ID WOS:000454172100013
Scopus ID 85042081624
PubMed ID 29439264
Erfassungsdatum 2018-06-04
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