Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
Publ. Version/Full Text
Postprint
DOI
PMC
 |
Open Access Gold |
|
as soon as is submitted to ZB.
Innate immunity of the lung: From basic mechanisms to translational medicine.
J. Innate Immun. 10, 487-501 (2018)
The respiratory tract is faced daily with 10,000 L of inhaled air. While the majority of air contains harmless environmental components, the pulmonary immune system also has to cope with harmful microbial or sterile threats and react rapidly to protect the host at this intimate barrier zone. The airways are endowed with a broad armamentarium of cellular and humoral host defense mechanisms, most of which belong to the innate arm of the immune system. The complex interplay between resident and infiltrating immune cells and secreted innate immune proteins shapes the outcome of host-pathogen, host-allergen, and host-particle interactions within the mucosal airway compartment. Here, we summarize and discuss recent findings on pulmonary innate immunity and highlight key pathways relevant for biomarker and therapeutic targeting strategies for acute and chronic diseases of the respiratory tract. (c) 2018 S. Karger AG, Basel
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Review
Keywords
Lung ; Immunity ; Immune Cells ; Neutrophils ; Macrophages ; Innate Lymphoid Cells ; Epithelial Cells; Invariant T-cells; Neutrophil Extracellular Traps; Obstructive Pulmonary-disease; Human Chitotriosidase Gene; Cystic-fibrosis Airways; Vitamin-b Metabolites; Sweet Taste Receptors; Lymphoid-cells; Mait Cells; Cxcr2 Antagonist
ISSN (print) / ISBN
1662-811X
e-ISSN
1662-8128
Journal
Journal of Innate Immunity
Quellenangaben
Volume: 10,
Issue: 5-6,
Pages: 487-501
Publisher
Karger
Publishing Place
Allschwilerstrasse 10, Ch-4009 Basel, Switzerland
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Biology (LHI)