PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Kleinert, M. ; Clemmensen, C. ; Hofmann, S.M. ; Moore, M.C.* ; Renner, S.* ; Woods, S.C.* ; Huypens, P. ; Beckers, J. ; Hrabě de Angelis, M. ; Schürmann, A.* ; Bakhti, M. ; Klingenspor, M.* ; Heimann, M.* ; Cherrington, A.D.* ; Ristow, M.* ; Lickert, H. ; Wolf, E.* ; Havel, P.J.* ; Müller, T.D. ; Tschöp, M.H.

Animal models of obesity and diabetes mellitus.

Nat. Rev. Endocrinol. 14, 140-162 (2018)
Publ. Version/Full Text DOI PMC
Closed
Open Access Green as soon as Postprint is submitted to ZB.
More than one-third of the worldwide population is overweight or obese and therefore at risk of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more potent therapeutics are urgently required. This necessitates the continued use of animal models to discover, validate and optimize novel therapeutics for their safe use in humans. In order to improve the transition from bench to bedside, researchers must not only carefully select the appropriate model but also draw the right conclusions. In this Review, we consolidate the key information on the currently available animal models of obesity and diabetes and highlight the advantages, limitations and important caveats of each of these models.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
20.265
4.297
306
366
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Review
Keywords High-fat-diet; Induced Insulin-resistance; Hepatic Glucose-uptake; Zebrafish Danio-rerio; Body-mass Index; Beta-cell Failure; Ob-ob Mice; Brown Adipose-tissue; Leptin Receptor Lepr; Inhibits Food-intake
Language english
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 1759-5029
e-ISSN 1759-5037
Journal Nature Reviews - Endocrinology
Quellenangaben Volume: 14, Issue: 3, Pages: 140-162 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
Institute of Diabetes and Regeneration Research (IDR)
Institute of Experimental Genetics (IEG)
Institute of Stem Cell Research (ISF)
POF-Topic(s) 30201 - Metabolic Health
90000 - German Center for Diabetes Research
30204 - Cell Programming and Repair
Research field(s) Helmholtz Diabetes Center
Genetics and Epidemiology
Stem Cell and Neuroscience
PSP Element(s) G-502200-001
G-502200-006
G-502390-001
G-500600-004
G-500600-001
G-502300-001
G-501900-221
G-500800-001
DOI 10.1038/nrendo.2017.161
WOS ID WOS:000424668800014
Scopus ID 85041891766
PubMed ID 29348476
Erfassungsdatum 2018-02-27
[➜Report correction]