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Alleviation of trigeminal nociception using p75 neurotrophin receptor targeted lentiviral interference therapy.
Neurotherapeutics 15, 489-499 (2018)
Flatworms of the species Schmidtea mediterranea are immortal-adult animals contain a large pool of pluripotent stem cells that continuously differentiate into all adult cell types. Therefore, single-cell transcriptome profiling of adult animals should reveal mature and progenitor cells. By combining perturbation experiments, gene expression analysis, a computational method that predicts future cell states from transcriptional changes, and a lineage reconstruction method, we placed all major cell types onto a single lineage tree that connects all cells to a single stem cell compartment. We characterized gene expression changes during differentiation and discovered cell types important for regeneration. Our results demonstrate the importance of single-cell transcriptome analysis for mapping and reconstructing fundamental processes of developmental and regenerative biology at high resolution.
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Times Cited
Times Cited
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5.719
1.546
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1
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
P75ntr ; Capsaicin ; Trpv1 ; Neuropathic Pain ; Neurotherapeutics; Planarian Schmidtea-mediterranea; Stem-cells; Rna-seq; Gene-expression; Regeneration; Pluripotency; Trajectories; Organism; Tissues; System
Language
Publication Year
2018
HGF-reported in Year
2018
ISSN (print) / ISBN
1933-7213
e-ISSN
1878-7479
Journal
Neurotherapeutics
Quellenangaben
Volume: 15,
Issue: 2,
Pages: 489-499
Publisher
Springer
Publishing Place
New York, NY
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s)
30205 - Bioengineering and Digital Health
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-505500-001
WOS ID
WOS:000431510200021
Scopus ID
85041842279
PubMed ID
29427180
Erfassungsdatum
2018-03-05