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Jackson, M.A.* ; Bonder, M.J.* ; Kuncheva, Z.* ; Zierer, J. ; Fu, J.* ; Kurilshikov, A.* ; Wijmenga, C.* ; Zhernakova, A.* ; Bell, J.T.* ; Spector, T.D.* ; Steves, C.J.*

Detection of stable community structures within gut microbiota co-occurrence networks from different human populations.

PeerJ 6:e4303 (2018)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Microbes in the gut microbiome form sub-communities based on shared niche specialisations and specific interactions between individual taxa. The inter-microbial relationships that define these communities can be inferred from the co-occurrence of taxa across multiple samples. Here, we present an approach to identify comparable communities within different gut microbiota co-occurrence networks, and demonstrate its use by comparing the gut microbiota community structures of three geographically diverse populations. We combine gut microbiota profiles from 2,764 British, 1,023 Dutch, and 639 Israeli individuals, derive co-occurrence networks between their operational taxonomic units, and detect comparable communities within them. Comparing populations we find that community structure is significantly more similar between datasets than expected by chance. Mapping communities across the datasets, we also show that communities can have similar associations to host phenotypes in different populations. This study shows that the community structure within the gut microbiota is stable across populations, and describes a novel approach that facilitates comparative community-centric microbiome analyses.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Microbiome ; Gut ; Human ; Population ; Networks ; Co-occurrence ; Communities; Operational Taxonomic Units; Butyrate-producing Bacteria; Human Large-intestine; Scale-free Networks; Rna Gene-sequences; Assembly Rules; Biology; Metagenomics; Association; Enterotypes
ISSN (print) / ISBN 2167-8359
e-ISSN 2167-8359
Journal PeerJ
Quellenangaben Volume: 6, Issue: , Pages: , Article Number: e4303 Supplement: ,
Publisher PeerJ
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Bioinformatics and Systems Biology (IBIS)