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Hovanec, J.* ; Siemiatycki, J.* ; Conway, D.I.* ; Olsson, A.* ; Stücker, I.* ; Guida, F.* ; Jöckel, K.H.* ; Pohlabeln, H.* ; Ahrens, W.* ; Brüske, I. ; Wichmann, H.-E. ; Gustavsson, P.* ; Consonni, D.* ; Merletti, F.* ; Richiardi, L.* ; Simonato, L.* ; Fortes, C.* ; Parent, M.E.* ; McLaughlin, J.* ; Demers, P.* ; Landi, M.T.* ; Caporaso, N.* ; Tardón, A.* ; Zaridze, D.* ; Szeszenia-Dabrowska, N.* ; Rudnai, P.* ; Lissowska, J.* ; Fabianova, E.* ; Field, J.* ; Dumitru, R.S.* ; Bencko, V.* ; Foretova, L.* ; Janout, V.* ; Kromhout, H.* ; Vermeulen, R.* ; Boffetta, P.* ; Straif, K.* ; Schüz, J.* ; Kendzia, B.* ; Pesch, B.* ; Brüning, T.* ; Behrens, T.*

Lung cancer and socioeconomic status in a pooled analysis of case-control studies.

PLoS ONE 13:e0192999 (2018)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Background An association between low socioeconomic status (SES) and lung cancer has been observed in several studies, but often without adequate control for smoking behavior. We studied the association between lung cancer and occupationally derived SES, using data from the international pooled SYNERGY study. Methods Twelve case-control studies from Europe and Canada were included in the analysis. Based on occupational histories of study participants we measured SES using the International Socio-Economic Index of Occupational Status (ISEI) and the European Socio-economic Classification (ESeC). We divided the ISEI range into categories, using various criteria. Stratifying by gender, we calculated odds ratios (OR) and 95% confidence intervals (CI) by unconditional logistic regression, adjusting for age, study, and smoking behavior. We conducted analyses by histological subtypes of lung cancer and subgroup analyses by study region, birth cohort, education and occupational exposure to known lung carcinogens. Results The analysis dataset included 17,021 cases and 20,885 controls. There was a strong elevated OR between lung cancer and low SES, which was attenuated substantially after adjustment for smoking, however a social gradient persisted. SES differences in lung cancer risk were higher among men (lowest vs. highest SES category: ISEI OR 1.84 (95% CI 1.61-2.09); ESeC OR 1.53 (95% CI 1.44-1.63)), than among women (lowest vs. highest SES category: ISEI OR 1.54 (95% CI 1.20-1.98); ESeC OR 1.34 (95% CI 1.19-1.52)). Conclusion SES remained a risk factor for lung cancer after adjustment for smoking behavior.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Secondhand Smoke Exposure; Social-class Differences; Educational Inequalities; Occupational Exposures; Neck-cancer; Risk; Mortality; Health; Epidemiology; Bias
Language english
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 1932-6203
Journal PLoS ONE
Quellenangaben Volume: 13, Issue: 2, Pages: , Article Number: e0192999 Supplement: ,
Publisher Public Library of Science (PLoS)
Publishing Place Lawrence, Kan.
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-008
DOI 10.1371/journal.pone.0192999
WOS ID WOS:000425554200042
Scopus ID 85042607215
PubMed ID 29462211
Erfassungsdatum 2018-03-14
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