OpenSSL SSL_connect: Connection reset by peer in connection to v2.sherpa.ac.uk:443 PuSH - Publication Server of Helmholtz Zentrum München: Species fractionation in a case-control study concerning Parkinson's disease: Cu-amino acids discriminate CSF of PD from controls.

PuSH - Publication Server of Helmholtz Zentrum München

Willkommen, D. ; Lucio, M. ; Schmitt-Kopplin, P. ; Gazzaz, M.* ; Schroeter, M.L.* ; Sigaroudi, A.* ; Michalke, B.

Species fractionation in a case-control study concerning Parkinson's disease: Cu-amino acids discriminate CSF of PD from controls.

J. Trace Elem. Med. Biol. 49, 164-170 (2018)
Postprint DOI PMC
Open Access Green
Background: Parkinson's disease is affecting about 1% of the population above 65 years. Improvements in medicine support prolonged lifetime which increases the total concentration of humans affected by the disease. It is suggested that occupational and environmental exposure to metals like iron (Fe), manganese (Mn), copper (Cu) and zinc (Zn) can influence the risk for Parkinson's disease. These metals play a key role as cofactors in many enzymes and proteins.Methods: In this case-control study, we investigated the Mn-, Fe-, Cu- and Zn-species in cerebrospinal fluid (CSF) by size-exclusion chromatography hyphenated to inductively coupled plasma mass spectrometry (SEC-ICP-MS) and the total concentration of these metals by inductively coupled plasma sector field mass spectrometry (ICP-sf-MS).Results: The investigation of total metal concentration and speciation provided only minor changes, but it produced strong significance for a number of ratios. The analysis revealed a strong change in the ratio between total concentration of Fe and the amino acid-fraction of Cu. This could be observed when analyzing both the respective element concentrations of the fraction (which also depends on individual variation of the total element concentration) as well as when being expressed as percentage of total concentration (normalization) which more clearly shows changes of distribution pattern independent of individual variation of total element concentrations.Conclusion: Speciation analysis, therefore, is a powerful technique to investigate changes in a case-control study where ratios of different species play an important role.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Parkinson's Disease ; Cerebrospinal Fluid ; Speciation ; Element-ratio ; Trace Element; Cerebrospinal-fluid; Neurodegenerative Diseases; Alzheimers-disease; Oxidative Stress; Manganese Speciation; Substantia-nigra; Alpha-synuclein; Iron; Metals; Brain
ISSN (print) / ISBN 0946-672X
e-ISSN 1878-3252
Journal Journal of Trace Elements in Medicine and Biology
Quellenangaben Volume: 49, Issue: , Pages: 164-170 Article Number: , Supplement: ,
Publisher Urban & Fischer
Publishing Place Office Jena, P O Box 100537, 07705 Jena, Germany
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Research Unit BioGeoChemistry and Analytics (BGC)