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Myklatun, A. ; Lauri, A. ; Eder, S.H.K.* ; Cappetta, M. ; Shcherbakov, D.* ; Wurst, W. ; Winklhofer, M.* ; Westmeyer, G.G.

Zebrafish and medaka offer insights into the neurobehavioral correlates of vertebrate magnetoreception.

Nat. Commun. 9:802 (2018)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
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An impediment to a mechanistic understanding of how some species sense the geomagnetic field ("magnetoreception") is the lack of vertebrate genetic models that exhibit well-characterized magnetoreceptive behavior and are amenable to whole-brain analysis. We investigated the genetic model organisms zebrafish and medaka, whose young stages are transparent and optically accessible. In an unfamiliar environment, adult fish orient according to the directional change of a magnetic field even in darkness. To enable experiments also in juveniles, we applied slowly oscillating magnetic fields, aimed at generating conflicting sensory inputs during exploratory behavior. Medaka (but not zebrafish) increase their locomotor activity in this assay. Complementary brain activity mapping reveals neuronal activation in the lateral hindbrain during magnetic stimulation. These comparative data support magnetoreception in teleosts, provide evidence for a light-independent mechanism, and demonstrate the usefulness of zebrafish and medaka as genetic vertebrate models for studying the biophysical and neuronal mechanisms underlying magnetoreception.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Magnetic Compass Orientation; Radical-pair Mechanism; Loggerhead Sea-turtles; Subterranean Rodent; Migratory Birds; European Robins; Field Detection; Spiny Lobsters; Coil Systems; Brain-stem
Language english
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 9, Issue: 1, Pages: , Article Number: 802 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
Institute of Developmental Genetics (IDG)
POF-Topic(s) 30505 - New Technologies for Biomedical Discoveries
30205 - Bioengineering and Digital Health
30204 - Cell Programming and Repair
Research field(s) Enabling and Novel Technologies
Genetics and Epidemiology
PSP Element(s) G-552000-001
G-505592-001
G-500500-001
DOI 10.1038/s41467-018-03090-6
WOS ID WOS:000425935100015
Scopus ID 85042538581
PubMed ID 29476093
Erfassungsdatum 2018-03-05
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