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Open Access Green as soon as Postprint is submitted to ZB.
Pharmacological modulation of mitochondrial calcium homeostasis.
J. Physiol. 596, 2717-2733 (2018)
Mitochondria are pivotal organelles in calcium (Ca2+) handling and signalling, constituting intracellular checkpoints for numerous processes that are vital for cell life. Alterations in mitochondrial Ca2+ homeostasis have been linked to a variety of pathological conditions and are critical in the aetiology of several human diseases. Efforts have been taken to harness mitochondrial Ca2+ transport mechanisms for therapeutic intervention, but pharmacological compounds that direct and selectively modulate mitochondrial Ca2+ homeostasis are currently lacking. New avenues have, however, emerged with the breakthrough discoveries on the genetic identification of the main players involved in mitochondrial Ca2+ influx and efflux pathways and with recent hints towards a deep understanding of the function of these molecular systems. Here, we review the current advances in the understanding of the mechanisms and regulation of mitochondrial Ca2+ homeostasis and its contribution to physiology and human disease. We also introduce and comment on the recent progress towards a systems-level pharmacological targeting of mitochondrial Ca2+ homeostasis.
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Publication type
Article: Journal article
Document type
Review
Keywords
Mitochondria ; Calcium ; Drug Screening ; Calcium Signaling ; Mitochondrial Calcium Uniporter ; Drug Discovery; Rat-liver Mitochondria; Wolf-hirschhorn-syndrome; Local-anesthetic Drugs; Ca2+ Uptake; Ruthenium Red; Essential Component; Heart-mitochondria; Ion Transport; Cell-death; In-vivo
ISSN (print) / ISBN
0928-4257
e-ISSN
1769-7115
Journal
Journal of Physiology - Paris
Quellenangaben
Volume: 596,
Issue: 14,
Pages: 2717-2733
Publisher
Elsevier
Publishing Place
111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)