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Reber, J. ; Willershäuser, M.* ; Karlas, A. ; Paul-Yuan, K. ; Diot, G. ; Franz, D.* ; Fromme, T.* ; Ovsepian, S.V. ; Bézière, N. ; Dubikovskaya, E.* ; Karampinos, D.C.* ; Holzapfel, C.* ; Hauner, H.* ; Klingenspor, M.* ; Ntziachristos, V.

Non-invasive measurement of brown fat metabolism based on optoacoustic imaging of hemoglobin gradients.

Cell Metab. 27, 689-701.e4 (2018)

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Metabolism is a fundamental process of life. However, non-invasive measurement of local tissue metabolism is limited today by a deficiency in adequate tools for in vivo observations. We designed a multi-modular platform that explored the relation between local tissue oxygen consumption, determined by label-free optoacoustic measurements of hemoglobin, and concurrent indirect calorimetry obtained during metabolic activation of brown adipose tissue (BAT). By studying mice and humans, we show how video-rate handheld multi-spectral optoacoustic tomography (MSOT) in the 700-970 nm spectral range enables non-invasive imaging of BAT activation, consistent with positron emission tomography findings. Moreover, we observe BAT composition differences between healthy and diabetic tissues. The study consolidates hemoglobin as a principal label-free biomarker for longitudinal non-invasive imaging of BAT morphology and bioenergetics in situ. We also resolve water and fat components in volunteers, and contrast MSOT readouts with magnetic resonance imaging data.

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