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The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers.
Nat. Immunol. 19, 267–278 (2018)
Antibody affinity maturation occurs in germinal centers (GCs), where B cells cycle between the light zone (LZ) and the dark zone. In the LZ, GC B cells bearing immunoglobulins with the highest affinity for antigen receive positive selection signals from helper T cells, which promotes their rapid proliferation. Here we found that the RNA-binding protein PTBP1 was needed for the progression of GC B cells through late S phase of the cell cycle and for affinity maturation. PTBP1 was required for proper expression of the c-MYC-dependent gene program induced in GC B cells receiving T cell help and directly regulated the alternative splicing and abundance of transcripts that are increased during positive selection to promote proliferation.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
C-myc; Affinity Maturation; Dynamic Regulation; Center Light; Expression; Kinase; Mouse; Gene; Proliferation; Regulator
ISSN (print) / ISBN
1529-2908
e-ISSN
1529-2916
Journal
Nature Immunology
Quellenangaben
Volume: 19,
Issue: 3,
Pages: 267–278
Publisher
Nature Publishing Group
Publishing Place
New York
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Pancreatic Beta Cell Research (IPI)