PuSH - Publication Server of Helmholtz Zentrum München: Muscular strength is independently associated with cystatin C: The KORA-Age Study.

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Volaklis, K.A.* ; Thorand, B. ; Peters, A. ; Halle, M.* ; Heier, M. ; Amann, U. ; Ladwig, K.-H. ; Schulz, H. ; Koenig, W.* ; Meisinger, C.

Muscular strength is independently associated with cystatin C: The KORA-Age Study.

Int. J. Sports Med. 39, 225-231 (2018)

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The purpose of this study was to investigate if there is a link between muscular strength (MS) and markers of chronic kidney disease (CKD) among older adults. The cross-sectional analysis based on 1041 men and women, aged 65-94 years, who participated in the KORA-Age study. Participants underwent an interview and extensive examinations including anthropometric measurements, diseases and drug intake registration, determination of health-related behaviors, collection of blood samples for measurements of cystatin C and maximal muscle strength evaluation. One-Way ANOVA revealed significant differences in both mean cystatin C (1.16 +/- 0.37 vs. 1.03 +/- 0.29 vs. 0.93 +/- 0.24mg/L, p<0.001) and mean eGFRcysC (63.61 +/- 18.61 vs. 72.14 +/- 18.92 vs. 79.87 +/- 18.19ml/min/1.73m(2), p<0.05) across thirds of maximal muscular strength (from lowest to highest). MS in the lowest third was significantly associated with increased odds of having elevated cystatin C (OR: 1.70, 95% CI: 1.01-2.85, p=0.043) after controlling for age, gender, fat mass, fat-free mass, alcohol intake, smoking status, number of regularly used medications, multimorbidity status, hs-CRP, telomere length and levels of physical activity. Lower levels of MS are independently associated with higher concentrations of cystatin C and lower eGFRcysC in older individuals. Increasing the levels of muscular strength may be useful to prevent the age-related CKD disease of older adults.

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