Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
Publ. Version/Full Text
Research data
DOI
PMC
 |
|
Open Access Green as soon as Postprint is submitted to ZB.
Elevated levels of the reactive metabolite methylglyoxal recapitulate progression of type 2 diabetes.
Cell Metab. 27, 926-934.e8 (2018)
Publ. Version/Full Text
Research data
DOI
PMC
The molecular causes of type 2 diabetes (T2D) are not well understood. Both type 1 diabetes (T1D) and T2D are characterized by impaired insulin signaling and hyperglycemia. From analogy to T1D, insulin resistance and hyperglycemia are thought to also play causal roles in T2D. Recent clinical studies, however, found that T2D patients treated to maintain glycemia below the diabetes definition threshold (HbA(1c) < 6.5%) still develop diabetic complications. This suggests additional insulin-and glucose-independent mechanisms could be involved in T2D progression and/or initiation. T2D patients have elevated levels of the metabolite methylglyoxal (MG). We show here, using Drosophila glyoxalase 1 knockouts, that animals with elevated methylglyoxal recapitulate several core aspects of T2D: insulin resistance, obesity, and hyperglycemia. Thus elevated MG could constitute one root cause of T2D, suggesting that the molecular causes of elevated MG warrant further study.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Drosophila ; Glo1 ; Methylglyoxal; Dicarbonyl Detoxification; Cardiovascular-disease; Intensive Treatment; Aldose Reductase; Glycemic Control; Protein; Stress; Hyperglycemia; Perspective; Drosophila
ISSN (print) / ISBN
1550-4131
e-ISSN
1932-7420
Journal
Cell Metabolism
Quellenangaben
Volume: 27,
Issue: 4,
Pages: 926-934.e8
Publisher
Elsevier
Publishing Place
Cambridge
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Cancer (IDC)