PuSH - Publication Server of Helmholtz Zentrum München: Tumor-associated macrophages in human breast cancer produce new monocyte attracting and pro-angiogenic factor YKL-39 indicative for increased metastasis after neoadjuvant chemotherapy.

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Liu, T.* ; Larionova, I.* ; Litviakov, N.* ; Riabov, V.* ; Zavyalova, M.V.* ; Tsyganov, M.* ; Buldakov, M.* ; Song, B.* ; Moganti, K.* ; Kazantseva, P.* ; Slonimskaya, E.* ; Kremmer, E. ; Flatley, A. ; Klüter, H.* ; Cherdyntseva, N.V.* ; Kzhyshkowska, J.*

Tumor-associated macrophages in human breast cancer produce new monocyte attracting and pro-angiogenic factor YKL-39 indicative for increased metastasis after neoadjuvant chemotherapy.

OncoImmunology 7:e1436922 (2018)

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It is undeniably one of the greatest findings in biology that (with some very minor exceptions) every cell in the body possesses the whole genetic information needed to generate a complete individual. Today, this concept has been so thoroughly assimilated that we struggle to still see how surprising this finding actually was: all cellular phenotypes naturally occurring in one person are generated from genetic uniformity, and thus are per definition epigenetic. Transcriptional mechanisms are clearly critical for developing and protecting cell identities, because a mis-expression of few or even single genes can efficiently induce inappropriate cellular programmes. However, how transcriptional activities are molecularly controlled and which of the many known epigenomic features have causal roles remains unclear. Today, clarification of this issue is more pressing than ever because profiling efforts and epigenome-wide association studies (EWAS) continuously provide comprehensive datasets depicting epigenomic differences between tissues and disease states. In this commentary, we propagate the idea of a widespread follow-up use of epigenome editing technology in EWAS studies. This would enable them to address the questions of which features, where in the genome, and which circumstances are essential to shape development and trigger disease states.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Angiogenesis ; Breast Cancer ; Chemotaxis ; Chitinase-like Protein ; Monocyte ; Neoadjuvant Chemotherapy ; Tumor-associated Macrophage ; Ykl-39; Base-resolution Analysis; Dna-methylation; Wide Association; Transcription Factors; Mammalian Genome; Cells; System; Enhancers; Cancer; Genes

ISSN (print) / ISBN 2162-4011

e-ISSN 2162-402X

Journal OncoImmunology

Quellenangaben Volume: 7, Issue: 6, Article Number: e1436922

Publisher Taylor & Francis

Publishing Place Philadelphia

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Molecular Immunology (IMI)