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Traumatic brain injury: At the crossroads of neuropathology and common metabolic endocrinopathies.
J. Clin. Med. 7:59 (2018)
Flatworms of the species Schmidtea mediterranea are immortal-adult animals contain a large pool of pluripotent stem cells that continuously differentiate into all adult cell types. Therefore, single-cell transcriptome profiling of adult animals should reveal mature and progenitor cells. By combining perturbation experiments, gene expression analysis, a computational method that predicts future cell states from transcriptional changes, and a lineage reconstruction method, we placed all major cell types onto a single lineage tree that connects all cells to a single stem cell compartment. We characterized gene expression changes during differentiation and discovered cell types important for regeneration. Our results demonstrate the importance of single-cell transcriptome analysis for mapping and reconstructing fundamental processes of developmental and regenerative biology at high resolution.
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Publication type
Article: Journal article
Document type
Review
Keywords
Neuroendocrinology ; Endocrine Disorders ; Brain Injury ; Critical Illness ; Diabetes Mellitus ; Obesity ; Metabolic Syndrome ; Hypothyroidism ; Hypothalamic-pituitary Axis; Planarian Schmidtea-mediterranea; Stem-cells; Rna-seq; Gene-expression; Regeneration; Pluripotency; Trajectories; Organism; Tissues; System
ISSN (print) / ISBN
2077-0383
e-ISSN
2077-0383
Journal
Journal of Clinical Medicine
Quellenangaben
Volume: 7,
Issue: 3,
Article Number: 59
Publisher
MDPI
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)