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Traumatic brain injury: At the crossroads of neuropathology and common metabolic endocrinopathies.
J. Clin. Med. 7:59 (2018)
Flatworms of the species Schmidtea mediterranea are immortal-adult animals contain a large pool of pluripotent stem cells that continuously differentiate into all adult cell types. Therefore, single-cell transcriptome profiling of adult animals should reveal mature and progenitor cells. By combining perturbation experiments, gene expression analysis, a computational method that predicts future cell states from transcriptional changes, and a lineage reconstruction method, we placed all major cell types onto a single lineage tree that connects all cells to a single stem cell compartment. We characterized gene expression changes during differentiation and discovered cell types important for regeneration. Our results demonstrate the importance of single-cell transcriptome analysis for mapping and reconstructing fundamental processes of developmental and regenerative biology at high resolution.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Altmetric
5.583
1.535
6
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Publication type
Article: Journal article
Document type
Review
Keywords
Neuroendocrinology ; Endocrine Disorders ; Brain Injury ; Critical Illness ; Diabetes Mellitus ; Obesity ; Metabolic Syndrome ; Hypothyroidism ; Hypothalamic-pituitary Axis; Planarian Schmidtea-mediterranea; Stem-cells; Rna-seq; Gene-expression; Regeneration; Pluripotency; Trajectories; Organism; Tissues; System
Language
english
Publication Year
2018
HGF-reported in Year
2018
ISSN (print) / ISBN
2077-0383
e-ISSN
2077-0383
Journal
Journal of Clinical Medicine
Quellenangaben
Volume: 7,
Issue: 3,
Article Number: 59
Publisher
MDPI
Publishing Place
Basel
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)
POF-Topic(s)
30204 - Cell Programming and Repair
Research field(s)
Stem Cell and Neuroscience
PSP Element(s)
G-500800-001
WOS ID
WOS:000428509700023
PubMed ID
29538298
Erfassungsdatum
2018-03-22