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Fiedler, L.* ; Kellner, M. ; Gosewisch, A.* ; Oos, R.* ; Böning, G.* ; Lindner, S.* ; Albert, N.* ; Bartenstein, P.* ; Reulen, H.J.* ; Zeidler, R. ; Gildehaus, F.J.*

Evaluation of 177Lu[Lu]-CHX-A″-DTPA-6A10 Fab as a radioimmunotherapy agent targeting carbonic anhydrase XII.

Nucl. Med. Biol. 60, 55-62 (2018)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Flatworms of the species Schmidtea mediterranea are immortal-adult animals contain a large pool of pluripotent stem cells that continuously differentiate into all adult cell types. Therefore, single-cell transcriptome profiling of adult animals should reveal mature and progenitor cells. By combining perturbation experiments, gene expression analysis, a computational method that predicts future cell states from transcriptional changes, and a lineage reconstruction method, we placed all major cell types onto a single lineage tree that connects all cells to a single stem cell compartment. We characterized gene expression changes during differentiation and discovered cell types important for regeneration. Our results demonstrate the importance of single-cell transcriptome analysis for mapping and reconstructing fundamental processes of developmental and regenerative biology at high resolution.
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Publication type Article: Journal article
Document type Scientific Article
Keywords 177 Lu ; Carbonic Anhydrase Xii ; Fab ; Glioblastoma ; Radioimmunotherapy; Planarian Schmidtea-mediterranea; Stem-cells; Rna-seq; Gene-expression; Regeneration; Pluripotency; Trajectories; Organism; Tissues; System
Language english
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 0969-8051
e-ISSN 0969-8051
Journal Nuclear Medicine and Biology
Quellenangaben Volume: 60, Issue: , Pages: 55-62 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place 1200 New York Ave, Nw, Washington, Dc 20005 Usa
Reviewing status Peer reviewed
Institute(s) Research Unit Gene Vector (AGV)
POF-Topic(s)
30203 - Molecular Targets and Therapies
Research field(s)
Immune Response and Infection
PSP Element(s) G-508100-024
G-501500-007
DOI 10.1016/j.nucmedbio.2018.02.004
WOS ID WOS:000434369800007
Scopus ID 85044083216
PubMed ID 29571067
Erfassungsdatum 2018-04-09
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