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Tumor-derived extracellular vesicles activate primary monocytes.
Cancer Med. 7, 2013-2020 (2018)
Tumor cells educate immune effector cells in their vicinity by releasing factors that manipulate their phenotype and function. In fact, the thus generated immunosuppressive tumor microenvironment constitutes an integral part and a hallmark of solid tumors and contributes significantly to tumor development and immune escape. It has long been thought that soluble factors like prostaglandin E2 and TGF-β are the main mediators of these effects. But tumor cells also constantly release large number of extracellular vesicles (EVs), which are important conveyors of immune responses. We show here that tumor-derived EVs interact with primary monocytes and induce an activated phenotype, which is also observed in tumor-associated macrophages. Thus, both tumor-derived EVs and soluble factors together collaborate to form the immunosuppressive milieu of the tumor environment.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Extracellular Vesicles ; Immune Escape ; Tumor Microenvironment
ISSN (print) / ISBN
2045-7634
e-ISSN
2045-7634
Journal
Cancer Medicine
Quellenangaben
Volume: 7,
Issue: 5,
Pages: 2013-2020
Publisher
Wiley
Publishing Place
Hoboken, NJ
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Research Unit Gene Vector (AGV)