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Ordelheide, A.-M. ; Hrabě de Angelis, M. ; Häring, H.-U. ; Staiger, H.

Pharmacogenetics of oral antidiabetic therapy.

Pharmacogenomics 19, 577-587 (2018)
Postprint DOI PMC
Open Access Green
Type 2 diabetes prevalence is still on the rise worldwide. Antidiabetic drugs are widely prescribed to patients with Type 2 diabetes. Most patients start with metformin which is mostly well tolerated. However, a high percentage of patients fail to achieve glycemic control. The effectiveness of metformin as well as most other antidiabetic drugs depends among other factors on interindividual genetic differences that are up to now ignored in the treatment of Type 2 diabetes. Interestingly, many genes influencing the effectiveness of antidiabetic drugs are Type 2 diabetes risk genes making matters worse. Here, we shed light on these interindividual genetic differences.
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Publication type Article: Journal article
Document type Review
Keywords Interindividual Differences ; Oad ; Oral Antidiabetic Drugs ; T2d ; Type 2 Diabetes; Planarian Schmidtea-mediterranea; Stem-cells; Rna-seq; Gene-expression; Regeneration; Pluripotency; Trajectories; Organism; Tissues; System
Language english
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 1462-2416
e-ISSN 1744-8042
Journal Pharmacogenomics
Quellenangaben Volume: 19, Issue: 6, Pages: 577-587 Article Number: , Supplement: ,
Publisher Future Medicine
Publishing Place 1200 New York Ave, Nw, Washington, Dc 20005 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
Institute of Experimental Genetics (IEG)
POF-Topic(s) 90000 - German Center for Diabetes Research
30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
Genetics and Epidemiology
PSP Element(s) G-502400-001
G-500600-001
DOI 10.2217/pgs-2017-0195
WOS ID WOS:000432942300008
Scopus ID 85045465430
PubMed ID 29580198
Erfassungsdatum 2018-04-16
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