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André, V. ; Gau, C. ; Scheideler, A. ; Aguilar-Pimentel, J.A. ; Amarie, O.V. ; Becker, L. ; Garrett, L. ; Hans, W. ; Hölter, S.M. ; Janik, D. ; Moreth, K. ; Neff, F. ; Östereicher, M.A. ; Rácz, I. ; Rathkolb, B. ; Rozman, J. ; Bekeredjian, R.* ; Graw, J. ; Klingenspor, M.* ; Klopstock, T.* ; Ollert, M.* ; Schmidt-Weber, C.B. ; Wolf, E.* ; Wurst, W. ; Gailus-Durner, V. ; Brielmeier, M. ; Fuchs, H. ; Hrabě de Angelis, M.

Laboratory mouse housing conditions can be improved using common environmental enrichment without compromising data.

PLoS Biol. 16:e2005019 (2018)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Animal welfare requires the adequate housing of animals to ensure health and well-being. The application of environmental enrichment is a way to improve the well-being of laboratory animals. However, it is important to know whether these enrichment items can be incorporated in experimental mouse husbandry without creating a divide between past and future experimental results. Previous small-scale studies have been inconsistent throughout the literature, and it is not yet completely understood whether and how enrichment might endanger comparability of results of scientific experiments. Here, we measured the effect on means and variability of 164 physiological parameters in 3 conditions: with nesting material with or without a shelter, comparing these 2 conditions to a “barren” regime without any enrichments. We studied a total of 360 mice from each of 2 mouse strains (C57BL/6NTac and DBA/2NCrl) and both sexes for each of the 3 conditions. Our study indicates that enrichment affects the mean values of some of the 164 parameters with no consistent effects on variability. However, the influence of enrichment appears negligible compared to the effects of other influencing factors. Therefore, nesting material and shelters may be used to improve animal welfare without impairment of experimental outcome or loss of comparability to previous data collected under barren housing conditions.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 1544-9173
e-ISSN 1545-7885
Journal PLoS Biology
Quellenangaben Volume: 16, Issue: 4, Pages: , Article Number: e2005019 Supplement: ,
Publisher Public Library of Science (PLoS)
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
CF Comparative Medicine (AVM)
Institute of Developmental Genetics (IDG)
Institute of Pathology (PATH)
Institute for Allergy Research (IAF)
POF-Topic(s) 30201 - Metabolic Health
30202 - Environmental Health
30204 - Cell Programming and Repair
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Genetics and Epidemiology
Enabling and Novel Technologies
Allergy
PSP Element(s) G-500600-001
G-500900-001
G-500692-001
G-500500-001
G-500300-001
G-500500-002
G-505400-001
DOI 10.1371/journal.pbio.2005019
WOS ID WOS:000431480000026
Scopus ID 85046428535
PubMed ID 29659570
Erfassungsdatum 2018-05-03
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