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Rebling, J. ; Estrada, H. ; Gottschalk, S. ; Sela, G. ; Zwack, M. ; Wissmeyer, G. ; Ntziachristos, V. ; Razansky, D.

Dual-wavelength hybrid optoacoustic-ultrasound biomicroscopy for functional imaging of large-scale cerebral vascular networks.

J. Biophotonics 11:e201800057 (2018)

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	Open Access Green

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A critical link exists between pathological changes of cerebral vasculature and diseases affecting brain function. Microscopic techniques have played an indispensable role in the study of neurovascular anatomy and functions. Yet, investigations are often hindered by suboptimal trade-offs between the spatiotemporal resolution, field-of-view (FOV) and type of contrast offered by the existing optical microscopy techniques. We present a hybrid dual-wavelength optoacoustic (OA) biomicroscope capable of rapid transcranial visualization of large-scale cerebral vascular networks. The system offers 3-dimensional views of the morphology and oxygenation status of the cerebral vasculature with single capillary resolution and a FOV exceeding 6 x 8 mm(2), thus covering the entire cortical vasculature in mice. The large-scale OA imaging capacity is complemented by simultaneously acquired pulse-echo ultrasound (US) biomicroscopy scans of the mouse skull. The new approach holds great potential to provide better insights into cerebrovascular function and facilitate efficient studies into neurological and vascular abnormalities of the brain.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Blood Vessels ; Brain ; Cerebral ; Microscopy ; Photoacoustics ; Ultrasound; Resolution Photoacoustic Microscopy; Mouse-brain; Oxygen; Laser

ISSN (print) / ISBN 1864-063X

e-ISSN 1864-0648

Journal Journal of Biophotonics

Quellenangaben Volume: 11, Issue: 9, Article Number: e201800057

Publisher Wiley

Publishing Place Postfach 101161, 69451 Weinheim, Germany

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Biological and Medical Imaging (IBMI)