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Meiners, S. ; Evankovich, J.* ; Mallampalli, R.K.*

The ubiquitin proteasome system as a potential therapeutic target for systemic sclerosis.

Transl. Res., DOI: 10.1016/j.trsl.2018.03.003 (2018)
Postprint DOI PMC
Open Access Green
The present review aims to summarize available knowledge on the role of the ubiquitin-proteasome system (UPS) in the pathogenesis of scleroderma and scleroderma-related disease mechanisms. This will provide the reader with a more mechanistic understanding of disease pathogenesis and help to identify putative novel targets within the UPS for potential therapeutic intervention. Because of the heterogenous manifestations of scleroderma, we will primarily focus on conserved mechanisms that are involved in the development of lung scleroderma phenotypes.
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Publication type Article: Journal article
Document type Review
Language english
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 1931-5244
e-ISSN 1878-1810
Publisher Elsevier
Publishing Place New York, NY
Reviewing status Peer reviewed
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-501600-004
Scopus ID 85046716791
PubMed ID 29702079
Erfassungsdatum 2018-06-25