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as soon as is submitted to ZB.
The ubiquitin proteasome system as a potential therapeutic target for systemic sclerosis.
Transl. Res., DOI: 10.1016/j.trsl.2018.03.003 (2018)
The present review aims to summarize available knowledge on the role of the ubiquitin-proteasome system (UPS) in the pathogenesis of scleroderma and scleroderma-related disease mechanisms. This will provide the reader with a more mechanistic understanding of disease pathogenesis and help to identify putative novel targets within the UPS for potential therapeutic intervention. Because of the heterogenous manifestations of scleroderma, we will primarily focus on conserved mechanisms that are involved in the development of lung scleroderma phenotypes.
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Publication type
Article: Journal article
Document type
Review
ISSN (print) / ISBN
1931-5244
e-ISSN
1878-1810
Journal
Translational research
Publisher
Elsevier
Publishing Place
New York, NY
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Lung Health and Immunity (LHI)