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Rebling, J. ; Oyaga Landa, F.J. ; Dean-Ben, X.L. ; Douplik, A.* ; Razansky, D.

Integrated catheter for simultaneous radio frequency ablation and optoacoustic monitoring of lesion progression.

Opt. Lett. 43, 1886-1889 (2018)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Radio frequency (RF) catheter ablation is commonly used to eliminate dysfunctional cardiac tissue by heating via an alternating current. Clinical outcomes are highly dependent on careful anatomical guidance, electrophysiological mapping, and careful RF power titration during the procedure. Yet, current treatments rely mainly on the expertise of the surgeon to assess lesion formation, causing large variabilities in the success rate. We present an integrated catheter design suitable for simultaneous RF ablation and real-time optoacoustic monitoring of the forming lesion. The catheter design utilizes copper-coated multimode light guides capable of delivering both ablation current and near-infrared pulsed-laser illumination to the target tissue. The generated optoacoustic responses were used to visualize the ablation lesion formation in an ex-vivo bovine heart specimen in 3D. The presented catheter design enables the monitoring of ablation lesions with high spatiotemporal resolution while the overall therapy-monitoring approach remains compatible with commercially available catheter designs.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0146-9592
e-ISSN 1539-4794
Journal Optics Letters
Quellenangaben Volume: 43, Issue: 8, Pages: 1886-1889 Article Number: , Supplement: ,
Publisher Optical Society of America (OSA)
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)