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Albers, L.* ; Sobotzki, C.* ; Kuß, O.* ; Ajslev, T.* ; Batista, R.F.* ; Bettiol, H.* ; Brabin, B.* ; Buka, S.L.* ; Cardoso, V.C.* ; Clifton, V.L.* ; Devereux, G.* ; Gilman, S.E.* ; Grzeskowiak, L.E.* ; Heinrich, J. ; Hummel, S. ; Jacobsen, G.W.* ; Jones, G.* ; Koshy, G.* ; Morgen, C.S.* ; Oken, E.* ; Paus, T.* ; Pausova, Z.* ; Rifas-Shiman, S.L.* ; Sharma, A.J.* ; da Silva, A.A.* ; Sørensen, T.I.* ; Thiering, E. ; Turner, S.T.* ; Vik, T.* ; von Kries, R.*

Maternal smoking during pregnancy and offspring overweight: Is there a dose-response relationship? An individual patient data meta-analysis.

Int. J. Obes. 42, 1249-1264 (2018)
Publ. Version/Full Text Postprint DOI PMC
Open Access Green
Background/objectives A number of meta-analyses suggest an association between any maternal smoking in pregnancy and offspring overweight obesity. Whether there is a dose-response relationship across number of cigarettes and whether this differs by sex remains unclear.Subject/methods Studies reporting number of cigarettes smoked during pregnancy and offspring BMI published up to May 2015 were searched. An individual patient data meta-analysis of association between the number of cigarettes smoked during pregnancy and offspring overweight (defined according to the International Obesity Task Force reference) was computed using a generalized additive mixed model with non-linear effects and adjustment for confounders (maternal weight status, breastfeeding, and maternal education) and stratification for sex.Results Of 26 identified studies, 16 authors provided data on a total of 238,340 mother-child-pairs. A linear positive association was observed between the number of cigarettes smoked and offspring overweight for up to 15 cigarettes per day with an OR increase per cigarette of 1.03, 95% CI = [1.02-1.03]. The OR flattened with higher cigarette use. Associations were similar in males and females. Sensitivity analyses supported these results.Conclusions A linear dose-response relationship of maternal smoking was observed in the range of 1-15 cigarettes per day equally in boys and girls with no further risk increase for doses above 15 cigarettes.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Body-mass Index; Prenatal Exposure; Childhood Overweight; Parental Smoking; Cigarette-smoking; Tobacco-smoke; Risk-factors; Regression-analysis; Insulin-resistance; Nicotine Exposure
Language english
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 0307-0565
e-ISSN 1476-5497
Journal International Journal of Obesity
Quellenangaben Volume: 42, Issue: 7, Pages: 1249-1264 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place Macmillan Building, 4 Crinan St, London N1 9xw, England
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Institute of Diabetes Research (IDF)
POF-Topic(s) 30202 - Environmental Health
30201 - Metabolic Health
Research field(s) Genetics and Epidemiology
Helmholtz Diabetes Center
PSP Element(s) G-504000-008
G-502100-001
DOI 10.1038/s41366-018-0050-0
WOS ID WOS:000439346500001
Scopus ID 85046135540
PubMed ID 29717267
Erfassungsdatum 2018-06-25
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