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Rodriguez Camargo, D.C. ; Garg, D. ; Buday, K. ; Frankó, A. ; Rodriguez Camargo, A.* ; Schmidt, F.* ; Cox, S.J.* ; Suladze, S. ; Haslbeck, M.* ; Mideksa, Y.G.* ; Gemmecker, G.* ; Aichler, M. ; Mettenleiter, G. ; Schulz, M. ; Walch, A.K. ; Hrabě de Angelis, M. ; Feige, M.J.* ; Sierra, C.A.* ; Conrad, M. ; Tripsianes, K.* ; Ramamoorthy, A.* ; Reif, B.

hIAPP forms toxic oligomers in plasma.

Chem. Commun. 54, 5426-5429 (2018)
Postprint DOI PMC
Open Access Green
In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in β-sheet rich oligomers with increased β-cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 0009-241X
e-ISSN 1364-548X
Journal Chemical Communications
Quellenangaben Volume: 54, Issue: 43, Pages: 5426-5429 Article Number: , Supplement: ,
Publisher Royal Society of Chemistry (RSC)
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Structural Biology (STB)
Institute of Developmental Genetics (IDG)
Institute of Experimental Genetics (IEG)
Research Unit Analytical Pathology (AAP)