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Maida, A. ; Zota, A. ; Vegiopoulos, A.* ; Appak-Baskoy, S.* ; Augustin, H.G.* ; Heikenwalder, M.* ; Herzig, S. ; Rose, A.J.*

Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance.

J. Nutr. Biochem. 57, 189-196 (2018)
Postprint DOI PMC
Open Access Green
Recent studies have demonstrated that dietary protein dilution (PD) can promote metabolic inefficiency and improve glucose metabolism. However, whether PD can promote other aspects of metabolic health, such as improve systemic lipid metabolism, and mechanisms therein remains unknown. Mouse models of obesity, such as high-fat-diet-fed C57B1/6 N mice, and New Zealand Obese mice were fed normal (i.e., 20%P) and protein-dilute (i.e., 5%EP) diets. FGF21 -/-and Cd36-/-and corresponding littermate +/+ controls were also studied to examine gene-diet interactions. Here, we show that chronic PD retards the development of hypertrigylceridemia and fatty liver in obesity and that this relies on the induction of the hepatokine fibroblast growth factor 21 (FGF21). Furthermore, PD greatly enhances systemic lipid homeostasis, the mechanisms by which include FGF21-stimulated, and cluster of differentiation 36 (CD36) mediated, fatty acid clearance by oxidative tissues, such as heart and brown adipose tissue. Taken together, our preclinical studies demonstrate a novel nutritional strategy, as well as highlight a role for FGF21-stimulated systemic lipid metabolism, in combating obesity-related dyslipidemia.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Nutrition ; Transport ; Metabolism ; Fatty Liver ; Diet; Growth-factor 21; Increases Energy-expenditure; Improves Insulin Sensitivity; Fgf21 Regulates Metabolism; Male-mice; Nonalcoholic Steatohepatitis; Adipose-tissues; Amino-acids; Resistance; Health
ISSN (print) / ISBN 0955-2863
e-ISSN 0955-2863
Journal Journal of Nutritional Biochemistry, The
Quellenangaben Volume: 57, Issue: , Pages: 189-196 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place 360 Park Ave South, New York, Ny 10010-1710 Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)