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Gradl, R.* ; Dierolf, M.* ; Guenther, B.* ; Hehn, L.* ; Möller, W. ; Kutschke, D. ; Yang, L. ; Donnelley, M.* ; Murrie, R.* ; Erl, A. ; Stöger, T. ; Gleich, B.* ; Achterhold, K.* ; Schmid, O. ; Pfeiffer, F.* ; Morgan, K.S.*

In vivo dynamic phase-contrast X-ray Imaging using a compact light source.

Sci. Rep. 8:6788 (2018)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
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We describe the first dynamic and the first in vivo X-ray imaging studies successfully performed at a laser-undulator-based compact synchrotron light source. The X-ray properties of this source enable time-sequence propagation-based X-ray phase-contrast imaging. We focus here on non-invasive imaging for respiratory treatment development and physiological understanding. In small animals, we capture the regional delivery of respiratory treatment, and two measures of respiratory health that can reveal the effectiveness of a treatment; lung motion and mucociliary clearance. The results demonstrate the ability of this set-up to perform laboratory-based dynamic imaging, specifically in small animal models, and with the possibility of longitudinal studies.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Journal Scientific Reports
Quellenangaben Volume: 8, Issue: 1, Pages: , Article Number: 6788 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-505000-008
G-505000-001
DOI 10.1038/s41598-018-24763-8
WOS ID WOS:000431111300001
Scopus ID 85046398030
PubMed ID 29717143
Erfassungsdatum 2018-06-11
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