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Saller, M.M.* ; Huettl, R.E.* ; Mayer, J.M.* ; Feuchtinger, A. ; Krug, C.* ; Holzbach, T.* ; Volkmer, E.*

Validation of a novel animal model for sciatic nerve repair with an adipose-derived stem cell loaded fibrin conduit.

Neural Regen. Res. 13, 854-861 (2018)

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Flatworms of the species Schmidtea mediterranea are immortal-adult animals contain a large pool of pluripotent stem cells that continuously differentiate into all adult cell types. Therefore, single-cell transcriptome profiling of adult animals should reveal mature and progenitor cells. By combining perturbation experiments, gene expression analysis, a computational method that predicts future cell states from transcriptional changes, and a lineage reconstruction method, we placed all major cell types onto a single lineage tree that connects all cells to a single stem cell compartment. We characterized gene expression changes during differentiation and discovered cell types important for regeneration. Our results demonstrate the importance of single-cell transcriptome analysis for mapping and reconstructing fundamental processes of developmental and regenerative biology at high resolution.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Critical-size Nerve Defect ; Fibrin Conduit ; Autologous Nerve Transplant ; Peripheral Nerve Regeneration ; Adipose-derived Stem/progenitor Cells ; Sciatic Function Index ; Sciatic Nerve ; Re-innervation ; Axon Guidance ; Peripheral Circuitry; Planarian Schmidtea-mediterranea; Stem-cells; Rna-seq; Gene-expression; Regeneration; Pluripotency; Trajectories; Organism; Tissues; System

ISSN (print) / ISBN 1876-7958

e-ISSN 1673-5374

Journal Neural regeneration research

Quellenangaben Volume: 13, Issue: 5, Pages: 854-861

Publisher Wolters Kluwer Health Medknow

Publishing Place Mumbai

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Research Unit Analytical Pathology (AAP)