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Quantum dots cause acute systemic toxicity in lactating rats and growth restriction of offspring.
Nanoscale 10, 11564-11577 (2018)
The in vivo toxicity of QDs in animals has been broadly studied; however, their reproductive toxicity towards lactating rodents is currently unknown. This study therefore aims to assess the potential toxicity against dams and offspring after postnatal QD exposure at two doses (5 and 1 nmol per rat) and unravel whether QDs can translocate to pups via breastfeeding. The dose-dependent systemic toxicity of QDs in dams was observed by examining the body weight, hematology, biochemistry, histopathological changes, and sex hormone levels. It was found that the QDs primarily accumulated in the liver and spleen of dams at 1 day post injection (dpi), but the highest concentrations were found in the kidneys at 18 dpi. A few QDs were detected in breast milk and stomach and intestine of pups; this suggested that the QDs were transmitted to breast milk via blood circulation and then transferred to pups via breastfeeding. High-dose QDs induced severe growth inhibition and a 71.08% offspring mortality, while pups showed growth restriction within 90 dpi in the low-dose group. Moreover, the hematology, biochemistry, and histology results showed limited chronic toxicity against offspring in the long term. This study provides a theoretical foundation for the exposure assessment of nanomaterials in lactating animals and for the advancement of QDs in the biomedical field.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Titanium-dioxide Nanoparticles; In-vivo Distribution; Silver Nanoparticles; Carbon Nanotubes; Gold Nanoparticles; Fetal-development; Pregnant Mice; Exposure; Biodistribution; Pharmacokinetics
ISSN (print) / ISBN
2040-3364
e-ISSN
2040-3372
Journal
Nanoscale
Quellenangaben
Volume: 10,
Issue: 24,
Pages: 11564-11577
Publisher
Royal Society of Chemistry (RSC)
Publishing Place
Cambridge
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Lung Health and Immunity (LHI)