PuSH - Publication Server of Helmholtz Zentrum München: Association between abdominal adiposity and subclinical measures of left-ventricular remodeling in diabetics, prediabetics and normal controls without history of cardiovascular disease as measured by magnetic resonance imaging: Results from the KORA-FF4 Study.

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Schlett, C.L.* ; Lorbeer, R.* ; Arndt, C.* ; Auweter, S.* ; Machann, J. ; Hetterich, H.* ; Linkohr, B. ; Rathmann, W.* ; Peters, A. ; Bamberg, F.*

Association between abdominal adiposity and subclinical measures of left-ventricular remodeling in diabetics, prediabetics and normal controls without history of cardiovascular disease as measured by magnetic resonance imaging: Results from the KORA-FF4 Study.

Cardiovasc. Diabetol. 17, 88:88 (2018)

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Skin affections after sulfur mustard (SM) exposure include erythema, blister formation and severe inflammation. An antidote or specific therapy does not exist. Anti-inflammatory compounds as well as substances counteracting SM-induced cell death are under investigation. In this study, we investigated the benzylisoquinoline alkaloide berberine (BER), a metabolite in plants like berberis vulgaris, which is used as herbal pharmaceutical in Asian countries, against SM toxicity using a well-established in vitro approach. Keratinocyte (HaCaT) mono-cultures (MoC) or HaCaT/THP-1 co-cultures (CoC) were challenged with 100, 200 or 300 mM SM for 1 h. Post-exposure, both MoC and CoC were treated with 10, 30 or 50 mu M BER for 24 h. At that time, supernatants were collected and analyzed both for interleukine (IL) 6 and 8 levels and for content of adenylate-kinase (AK) as surrogate marker for cell necrosis. Cells were lysed and nucleosome formation as marker for late apoptosis was assessed. In parallel, AK in cells was determined for normalization purposes. BER treatment did not influence necrosis, but significantly decreased apoptosis. Anti-inflammatory effects were moderate, but also significant, primarily in CoC. Overall, BER has protective effects against SM toxicity in vitro. Whether this holds true should be evaluated in future in vivo studies.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Magnetic Resonance Imaging ; Intra-abdominal Fat ; Fatty Liver ; Ventricular Remodeling ; Diabetes Mellitus; Cell-line Thp-1; In-vitro; Hacat Keratinocytes; Alkaloid Berberine; Dendritic Cells; Injury; Skin; Sensitization; Expression; Toxicity

ISSN (print) / ISBN 1475-2840

e-ISSN 1475-2840

Journal Cardiovascular Diabetology

Quellenangaben Volume: 17, Issue: 1, Pages: 88 Article Number: 88

Publisher BioMed Central

Publishing Place Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
Institute of Epidemiology II (EPI2)