Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
Postprint
DOI
PMC
 |
Open Access Green |
as soon as is submitted to ZB.
Metabolic flexibility of a prospective bioremediator: Desulfitobacterium hafniense Y51 challenged in chemostats.
Environ. Microbiol. 20, 2652-2669 (2018)
Desulfitobacterium hafniense Y51 has been widely used in investigations of perchloroethylene (PCE) biodegradation, but limited information exists on its other physiological capabilities. We investigated how D. hafniense Y51 confronts the debilitating limitations of not having enough electron donor (lactate), or electron acceptor (fumarate) during cultivation in chemostats. The residual concentrations of the substrates supplied in excess were much lower than expected. Transcriptomics, proteomics and fluxomics were integrated to investigate how this phenomenon was regulated. Through diverse regulation at both transcriptional and translational levels, strain Y51 turned to fermenting the excess lactate and disproportionating the excess fumarate under fumarate- and lactate-limiting conditions respectively. Genes and proteins related to the utilization of a variety of alternative electron donors and acceptors absent from the medium were induced, apparently involving the Wood-Ljungdahl pathway. Through this me tabolic flexibility, D. hafniense Y51 may be able to switch between different metabolic capabilities under limiting conditions.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Complete Genome Sequence; Sp Strain Y51; Saccharomyces-cerevisiae; Continuous-culture; Dehalococcoides-ethenogenes; Dechlorinating Bacterium; Geobacter-sulfurreducens; Peptide Identification; Transcriptome Analysis; Gene-expression
ISSN (print) / ISBN
1462-2912
e-ISSN
1462-2920
Journal
Environmental Microbiology
Quellenangaben
Volume: 20,
Issue: 7,
Pages: 2652-2669
Publisher
Wiley
Publishing Place
111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed