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Forns, J.* ; Sunyer, J.* ; García-Esteban, R.* ; Porta, D.* ; Ghassabian, A.* ; Giorgis-Allemand, L.* ; Gong, T.* ; Gehring, U.* ; Sørensen, M.* ; Standl, M. ; Sugiri, D.* ; Almqvist, C.* ; Andiarena, A.* ; Badaloní, C.* ; Beelen, R.* ; Berdel, D.* ; Cesaroni, G.* ; Charles, M.A.* ; Eriksen, K.T.* ; Estarlich, M.* ; Fernández, M.F.* ; Forhan, A.* ; Jaddoe, V.W.V.* ; Korek, M.* ; Lichtenstein, P.* ; Lertxundi, A.* ; Lopez-Espinosa, M.J.* ; Markevych, I. ; de Nazelle, A.* ; Raaschou-Nielsen, O.* ; Nieuwenhuijsen, M.* ; Pérez-Lobato, R.* ; Philippat, C.* ; Slama, R.* ; Tiesler, C.M. ; Verhulst, F.C.* ; von Berg, A.* ; Vrijkotte, T.G.* ; Nybo Andersen, A.M.* ; Heude, B.* ; Krämer, U.* ; Heinrich, J. ; Tiemeier, H.* ; Forastiere, F.* ; Pershagen, G.* ; Brunekreef, B.* ; Guxens, M.*

Air pollution exposure during pregnancy and symptoms of attention deficit and hyperactivity disorder in children in Europe.

Epidemiology 29, 618-626 (2018)
Postprint DOI PMC
Open Access Green
BACKGROUND: Exposure to air pollution during pregnancy may increase attention-deficit/hyperactivity disorder (ADHD) symptoms in children, but findings have been inconsistent. We aimed to study this association in a collaborative study of eight European population-based birth/child cohorts, including 29,127 mother-child pairs. METHODS: Air pollution concentrations (nitrogen dioxide [NO2] and particulate matter [PM]) were estimated at the birth address by land-use regression models based on monitoring campaigns performed between 2008 and 2011. We extrapolated concentrations back in time to exact pregnancy periods. Teachers or parents assessed ADHD symptoms at 3-10 years of age. We classified children as having ADHD symptoms within the borderline/clinical range and within the clinical range using validated cutoffs. We combined all adjusted area-specific effect estimates using random-effects meta-analysis and multiple imputations and applied inverse probability-weighting methods to correct for loss to follow-up. RESULTS: We classified a total of 2,801 children as having ADHD symptoms within the borderline/clinical range, and 1,590 within the clinical range. Exposure to air pollution during pregnancy was not associated with a higher odds of ADHD symptoms within the borderline/clinical range (e.g., adjusted odds ratio [OR] for ADHD symptoms of 0.95, 95% confidence interval [CI] = 0.89, 1.01 per 10 µg/m increase in NO2 and 0.98, 95% CI = 0.80, 1.19 per 5 µg/m increase in PM2.5). We observed similar associations for ADHD within the clinical range. CONCLUSIONS: There was no evidence for an increase in risk of ADHD symptoms with increasing prenatal air pollution levels in children aged 3-10 years. See video abstract at, http://links.lww.com/EDE/B379.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Attention Deficit Disorder With Hyperactivity ; Child Development ; Environmental Pollution ; Longitudinal Studies ; Meta-analysis ; Nitrogen Oxides ; Particulate Matter ; Prospective Studies; Polycyclic Aromatic-hydrocarbons; Use Regression-models; Deficit/hyperactivity Disorder; Escape Project; Difficulties Questionnaire; Psychotropic Medications; Behavioral-problems; Pm2.5 Absorbency; Cohort Profile; City Children
ISSN (print) / ISBN 1044-3983
e-ISSN 1531-5487
Journal Epidemiology
Quellenangaben Volume: 29, Issue: 5, Pages: 618-626 Article Number: , Supplement: ,
Publisher Lippincott Williams & Wilkins
Publishing Place Two Commerce Sq, 2001 Market St, Philadelphia, Pa 19103 Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)