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Desbonnet, L.* ; Garrett, L. ; Clarke, G.* ; Kiely, B.* ; Cryan, J.F.* ; Dinan, T.G.*

Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.

Neuroscience 170, 1179-1188 (2010)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The concept that intestinal microbial composition not only affects the health of the gut, but also influences centrally-mediated systems involved in mood, is supported by a growing body of literature. Despite the emergent interest in brain-gut communication and its possible role in the pathogenesis of psychiatric disorders such as depression, particularly subtypes with accompanying gastrointestinal (GI) symptoms, there are few studies dedicated to the search for therapeutic solutions that address both central and peripheral facets of these illnesses. This study aims to assess the potential benefits of the probiotic Bifidobacterium infantis in the rat maternal separation (MS) model, a paradigm that has proven to be of value in the study of stress-related GI and mood disorders. MS adult rat offsprings were chronically treated with bifidobacteria or citalopram and subjected to the forced swim test (FST) to assess motivational state. Cytokine concentrations in stimulated whole blood samples, monoamine levels in the brain, and central and peripheral hypothalamic-pituitary-adrenal (HPA) axis measures were also analysed. MS reduced swim behavior and increased immobility in the FST, decreased noradrenaline (NA) content in the brain, and enhanced peripheral interleukin (IL)-6 release and amygdala corticotrophin-releasing factor mRNA levels. Probiotic treatment resulted in normalization of the immune response, reversal of behavioral deficits, and restoration of basal NA concentrations in the brainstem. These findings point to a more influential role for bifidobacteria in neural function, and suggest that probiotics may have broader therapeutic applications than previously considered.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Bifidobacteria; Probiotic; Maternal Separation; Depression; Forced swim test; Cytokines
ISSN (print) / ISBN 0306-4522
e-ISSN 1873-7544
Journal Neuroscience
Quellenangaben Volume: 170, Issue: 4, Pages: 1179-1188 Article Number: , Supplement: ,
Publisher International Brain Research Organization, Elsevier
Publishing Place Oxford
Non-patent literature Publications
Reviewing status Peer reviewed