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Real, F.G.* ; Burgess, J.A.* ; Villani, S.* ; Dratva, J.* ; Heinrich, J. ; Janson, C.* ; Jarvis, D.* ; Koplin, J.* ; Leynaert, B.* ; Lodge, C.J.* ; Laerum, B.N.* ; Matheson, M.C.* ; Norbäck, D.* ; Omenaas, E.R.* ; Skulstad, S.M.* ; Sunyer, J.* ; Dharmage, S.C.* ; Svanes, C.*

Maternal age at delivery, lung function and asthma in offspring: A population-based survey.

Eur. Respir. J. 51:1601611 (2018)
Publ. Version/Full Text Research data DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
There is limited information about potential impact of maternal age on the respiratory health of offspring. We investigated the association of maternal age at delivery with adult offspring’s lung function, respiratory symptoms and asthma, and potential differences according to offspring sex. 10692 adults from 13 countries participating in the European Community Respiratory Health Survey (ECRHS) II responded to standardised interviews and provided lung function measurements and serum for IgE measurements at age 25–55 years. In logistic and linear multilevel mixed models we adjusted for participants’ characteristics (age, education, centre, number of older siblings) and maternal characteristics (smoking in pregnancy, education) while investigating for differential effects by sex. Maternal age was validated in a subsample using data from the Norwegian birth registry. Increasing maternal age was associated with increasing forced expiratory volume in 1 s (2.33 mL per year, 95% CI 0.34–4.32 mL per year), more consistent in females (ptrend 0.025) than in males (ptrend 0.14). Asthma (OR 0.85, 95% CI 0.79–0.92) and respiratory symptoms (OR 0.87, 95% CI 0.82–0.92) decreased with increasing maternal age (per 5 years) in females, but not in males (pinteraction 0.05 and 0.001, respectively). The results were consistent across centres and not explained by confounding factors. Maternal ageing was related to higher adult lung function and less asthma/symptoms in females. Biological characteristics in offspring related to maternal ageing are plausible and need further investigation.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Pml Nuclear-bodies; Monoclonal-antibodies; E1b-55k Oncoprotein; Messenger-rna; E3 Ligase; Dependent Degradation; 55-kilodalton Protein; Transformed-cells; Cellular-proteins; E1b55k Proteins
ISSN (print) / ISBN 0903-1936
e-ISSN 1399-3003
Journal European Respiratory Journal
Quellenangaben Volume: 51, Issue: 6, Pages: , Article Number: 1601611 Supplement: ,
Publisher European Respiratory Society
Publishing Place Sheffield
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)