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Ziegler, A.-G. ; Ohli, J. ; Hoefs, T. ; Aydin, S.E. ; Falk, C. ; Gross, J.

Früherkennung und Primärprävention des Typ-1-Diabetes: „Global Platform for the Prevention of Autoimmune Diabetes“ (GPPAD).

Early detection and primary prevention of type 1 diabetes: Global Platform for the Prevention of Autoimmune Diabetes (GPPAD).

Diabetologie 14, 240-244 (2018)
Postprint DOI
Open Access Green
Background: Betacell autoimmunity, which leads to type 1 diabetes, starts in early childhood with a peak in incidence at 12 months and insulin is its primary target. GPPAD (Global Platform for the Prevention of Autoimmune Diabetes): This network of collaborating European scientists aims to realize the early detection of an elevated risk to develop type 1 diabetes and primary prevention of betacell autoimmunity and type 1 diabetes in Europe. A new genetic risk score can identify newborns with 25-fold increased risk of type 1 diabetes. These children can participate in a primary prevention trial called POInT (Primary Oral Insulin Trial). POInT study: This is a randomized, placebo-controlled, double-blind clinical trial that will test the efficacy of oral insulin to prevent autoimmunity and type 1 diabetes.
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Publication type Article: Journal article
Document type Review
Keywords Autoimmune Diabetes ; Genetic Predisposition To Disease ; Genetic Testing ; Infant, Newborn ; Insulin; Cell-line Thp-1; In-vitro; Hacat Keratinocytes; Alkaloid Berberine; Dendritic Cells; Injury; Skin; Sensitization; Expression; Toxicity
Language german
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 2731-7447
e-ISSN 2731-7455
Journal Diabetologie, Die
Quellenangaben Volume: 14, Issue: 4, Pages: 240-244 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research (IDF)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502100-001
DOI 10.1007/s11428-018-0337-8
WOS ID WOS:000434473300011
Scopus ID 85047167054
Erfassungsdatum 2018-07-09
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