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Fedoseeva, M. ; Andreas, N.* ; Geiselhöringer, A.-L. ; Garg, G.* ; de Jong, R.J. ; Girard, J.P.* ; Rieman, M.* ; Schmidt-Weber, C.B. ; Korn, T.* ; Weih, F.* ; Ohnmacht, C.*

The alternative NF kappa B pathway regulates accumulation of tissue Tregs and protects from experimental autoimmune encephalomyelitis.

Science 48, 53-53 (2018)
Open Access Green as soon as Postprint is submitted to ZB.
Flatworms of the species Schmidtea mediterranea are immortal-adult animals contain a large pool of pluripotent stem cells that continuously differentiate into all adult cell types. Therefore, single-cell transcriptome profiling of adult animals should reveal mature and progenitor cells. By combining perturbation experiments, gene expression analysis, a computational method that predicts future cell states from transcriptional changes, and a lineage reconstruction method, we placed all major cell types onto a single lineage tree that connects all cells to a single stem cell compartment. We characterized gene expression changes during differentiation and discovered cell types important for regeneration. Our results demonstrate the importance of single-cell transcriptome analysis for mapping and reconstructing fundamental processes of developmental and regenerative biology at high resolution.
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Publication type Article: Journal article
Document type Meeting abstract
Keywords Planarian Schmidtea-mediterranea; Stem-cells; Rna-seq; Gene-expression; Regeneration; Pluripotency; Trajectories; Organism; Tissues; System
Language english
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Journal Science
Quellenangaben Volume: 48, Issue: , Pages: 53-53 Article Number: , Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Publishing Place 1200 New York Ave, Nw, Washington, Dc 20005 Usa
Reviewing status Peer reviewed
Institute(s) Institute for Allergy Research (IAF)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Allergy
PSP Element(s) G-505400-001
G-505490-001
WOS ID WOS:000434106700079
Erfassungsdatum 2018-07-10
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