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Dawed, A.Y.* ; Mari, A.* ; McDonald, T.J.* ; Hong, M.-.* ; Sharma, S. ; Robertson, N.R.* ; Mahajan, A.* ; Walker, M.* ; Gough, S.C.* ; Zhou, K.* ; Forgie, I.* ; Ruetten, H.* ; Jones, A.G.* ; Pearson, E.R.*

GLP-1 receptor variants markedly differentiate glycaemic response to GLP-1 receptor agonists: A direct study.

Science 123, 13-14 (2018)
Open Access Green as soon as Postprint is submitted to ZB.
Flatworms of the species Schmidtea mediterranea are immortal-adult animals contain a large pool of pluripotent stem cells that continuously differentiate into all adult cell types. Therefore, single-cell transcriptome profiling of adult animals should reveal mature and progenitor cells. By combining perturbation experiments, gene expression analysis, a computational method that predicts future cell states from transcriptional changes, and a lineage reconstruction method, we placed all major cell types onto a single lineage tree that connects all cells to a single stem cell compartment. We characterized gene expression changes during differentiation and discovered cell types important for regeneration. Our results demonstrate the importance of single-cell transcriptome analysis for mapping and reconstructing fundamental processes of developmental and regenerative biology at high resolution.
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Publication type Article: Journal article
Document type Meeting abstract
Keywords Planarian Schmidtea-mediterranea; Stem-cells; Rna-seq; Gene-expression; Regeneration; Pluripotency; Trajectories; Organism; Tissues; System
Language
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Journal Science
Quellenangaben Volume: 123, Issue: , Pages: 13-14 Article Number: , Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Publishing Place 1200 New York Ave, Nw, Washington, Dc 20005 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 90000 - German Center for Diabetes Research
30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-501900-405
G-504091-002
WOS ID WOS:000434060000036
Erfassungsdatum 2018-07-10
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