PuSH - Publication Server of Helmholtz Zentrum München

Reiss, R.* ; Ehlert, S.* ; Heide, J.* ; Pütz, M.* ; Förster, T.* ; Zimmermann, R.

Ambient pressure laser desorption-chemical ionization mass spectrometry for fast and reliable detection of explosives, drugs, and their precursors.

Appl. Sci. 8:933 (2018)
Publ. Version/Full Text Research data DOI
Open Access Gold
Creative Commons Lizenzvertrag
Fast and reliable information is crucial for first responders to draw correct conclusions at crime scenes. An ambient pressure laser desorption (APLD) mass spectrometer is introduced for this scenario, which enables detecting substances on surfaces without sample pretreatment. It is especially useful for substances with low vapor pressure and thermolabile ones. The APLD allows for the separation of desorption and ionization into two steps and, therefore, both can be optimized separately. Within this work, an improved version of the developed system is shown that achieves limits of detection (LOD) down to 500 pg while remaining fast and flexible. Furthermore, realistic scenarios are applied to prove the usability of this system in real-world issues. For this purpose, post-blast residues of a bomb from the Second World War were analyzed, and the presence of PETN was proven without sample pretreatment. In addition, the analyzable substance range could be expanded by various drugs and drug precursors. Thus, the presented instrumentation can be utilized for an increased number of forensically important compound classes without changing the setup. Drug precursors revealed a LOD ranging from 6 to 100 ng. Drugs such as cocaine hydrochloride, heroin, (3,4-methylendioxy-methamphetamine) hydrochloride (MDMA) hydrochloride, and others exhibit a LOD between 10 to 200 ng.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
1.689
0.801
8
11
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Apld ; Drugs ; Explosives ; Post Blast Residue Detection ; Mass Spectrometry ; Chemical Ionization ; On-line Measurement ; Forensic Chemistry ; Mapping; Ion Mobility Spectrometry; Thermal-desorption; Illicit Drugs; Spectroscopy; Desorption/ionization; Samples; Dart; Ms; Identification; Chromatography
Language
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 2076-3417
e-ISSN 2076-3417
Quellenangaben Volume: 8, Issue: 6, Pages: , Article Number: 933 Supplement: ,
Publisher MDPI
Publishing Place Basel
Reviewing status Peer reviewed
POF-Topic(s) 30202 - Environmental Health
Research field(s) Environmental Sciences
PSP Element(s) G-504500-001
Scopus ID 85048079049
Erfassungsdatum 2018-07-12